Evaluation of short-term efficacy of 18F-FDG PET/CT in children with neuroblastoma

MA Qiuman; LI Yanshan; WANG Jun; MIAO Lixia; SUN Yanfeng; LIU Hongyan; YUAN Hailian; ZHANG Xianglan; and LIU Qiuling

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Medical Journal of the Chinese People Armed Police Forces ›› 2016, Vol. 27 ›› Issue (7) : 661-665.

Orignal Article

Evaluation of short-term efficacy of ¹⁸F-FDG PET/CT in children with neuroblastoma

MA Qiuman¹, LI Yanshan², WANG Jun², MIAO Lixia², SUN Yanfeng², LIU Hongyan², YUAN Hailian², ZHANG Xianglan², and LIU Qiuling^1,2

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Abstract

Objective To investigate the clinical value in the evaluation of the short-term efficacy of ¹⁸F-FDG PET/CT in children with neuroblastoma (NB).Methods Clinical data of 14 NB patients undergoing ¹⁸F-FDG PET/CT examination were recruited from April 2012 to April 2015 in this hospital. We evaluated the therapeutic efficacy in NB children and detected recurrent lesions.Results 14 NB children received totally 18 times ¹⁸F-FDG PET/CT examinations. Among them, 8 cases showed different degree and different parts with abnormal increased uptake of FDG, which guided to adjusting clinical treatment promptly.¹⁸F-FDG PET/CT changed one case’s stage, increasing from the initial stage Ⅳs to stage Ⅳ. 4 children who suffered relapse had a total of 17 lesions. The detection rate of ¹⁸F-FDG PET/CT for recurrent and metastatic lesions was 88.2% (15/17), missing one small intracranial metastasis and one case of bone marrow micro-metastasis.Conclusions ¹⁸F-FDG PET/CT has an important value in the evaluation of the short-term efficacy of NB children, and can be used as follow-up examination of NB in children.

Key words

neuroblastoma / positron emission computerized tomography / children / efficacy evaluation

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MA Qiuman, LI Yanshan, WANG Jun, MIAO Lixia, SUN Yanfeng, LIU Hongyan, YUAN Hailian, ZHANG Xianglan, and LIU Qiuling. Evaluation of short-term efficacy of ¹⁸F-FDG PET/CT in children with neuroblastoma[J]. Medical Journal of the Chinese People Armed Police Forces. 2016, 27(7): 661-665

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