Association between severe preeclampsia and mononmine oxidase A gene

SUN Yan; HOU Xuejing; and GUO Hongmei

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Medical Journal of the Chinese People Armed Police Forces ›› 2016, Vol. 27 ›› Issue (7) : 724-726.

Orignal Article

Association between severe preeclampsia and mononmine oxidase A gene

SUN Yan¹, HOU Xuejing¹,and GUO Hongmei²

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Abstract

Objective To analyze the impact of this polymorphism of monoamine oxidase A(MAO-A) variable number tandem repeat (VNTR) on the risk of severe preeclampsia.Methods Sixty pregnant women wih severe preeclampsia and seventy normal pregnant women were genotyped for MAO-A VNTR polymorphism using PCR-based restriction fragment length polymorphism method.Results Significant differences were not observed between the case group and normal controls in the frequencies of MAO-A VNTR alleles and genotypes.Conclusions There is no significant difference in the allele and genotype frequencies of MAO-A gene between case group and normal controls . Our results show that MAO-A VNTR polymorphism perhaps can no increase the risk of severe preeclampsia.

Key words

severe preeclampsia / MAO-A / gene polymorphism

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SUN Yan, HOU Xuejing,and GUO Hongmei. Association between severe preeclampsia and mononmine oxidase A gene[J]. Medical Journal of the Chinese People Armed Police Forces. 2016, 27(7): 724-726

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