Objective To investigate the expression of TGF-β, Ezrin and FGF-2 in 7, 12 - dimethyl-benzo [A] anthracene (DMBA) induced golden hamster oral cancer model and evaluate the role of TGF-β, Ezrin and FGF-2 in oral mucosal precancerosis process.Methods The unilateral cheek mucosa of the golden hamsters was treated with 0.5% DMBA and a series of samples were obtained. The expression of TGF-β, Ezrin and FGF-2 was examined by immunohistochemistry. Meanwhile, the correlation between the expressions of these three factors was analyzed.Results In moderate to severe epithelial dysplasia and early cancer groups the high TGF-β-positive rate was 75% and 100% respectively, while high FGF-2-posotive rates was 83% and 72% and high expression rate of Ezrin was 79% and 77%. Compared with mild epithelial dysplasia group and normal mucosa group, there was a significant difference (P＜0.01). Furthermore, there was a significant correlation among the expressions of TGF-β, Ezrin and FGF-2.Conclusions TGF-β, Ezrin and FGF-2 may play an important role and have an interaction effect in the carcinogenesis of oral squamous cell carcinoma.
Key words
golden hamster oral cancer model /
oral squamous cell carcinoma /
transforming growth factor-beta(TGF-β) /
basic fibroblast growth factor (FGF-2) /
Ezrin
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