Objective To study the efficacy of resveratrol soft capsules on fasting blood glucose and early diabetic retinopathy(DR).Methods 60 diabetic patients with DR were randomly divided into 4 groups: A, C, B and D by using digital table method.15 cases in each group.The first three groups received basic treatment plus resveratrol soft capsules, Group A: 250 mg/ead time, orally, twice/day; Group B: 350 mg/each times, orally,twice/day; Group C: 500 mg/each time, orally, twice/day for 12 weeks. D group was the control group (basic treatment: exercise intervention, diet control, insulin and oral hypoglycemic agents), compared before and after treatment 1,8,10,12 weekend DR fasting glucose.And before medication and 12 weeks,retinal fluorescein angiography (fundus fluorescence angiography FFA) was used to detect microvascular changes in the patient’s capillary hemangioma,hemorrhage and leakage area for comparison.Results In C group,after treatment ,FPG(8.6±0.812)mmol/L ratio(6.7±0.714)mmol/L,t=4.752,P=0.037;HbALc:(8.7±0.341)% versus(7.2±0.426)%,t=5.542,P=0.031,ISN:(32.4 ± 0.341)pmol/ml versus (28.3±0.132) pmol/ml,t=6.459,P=0.038,In after group C and D, capillary hemangioma, hemorrhage focal area and leaking focal area were (16.86±1.75)N versas (10.06±1.29)N,t=4.624, P＜0.05;(2.24±0.23)mm² versas(1.45±0.22) mm²,t=2.532, P＜0.05,(1.40±0.15) mm² versas(1.01±0.23) mm²,t=2.605, P＜0.05.After treatment, the number of capillary hemangioma was decreased, the area of hemorrhage and the area of leakage were reduced.Conclusions The effect of resveratrol on blood glucose and early retinopathy in diabetic patients is dose dependent,and the effective rate in group C is better than that in group B, and group B was better than groups A and D.