Objective To study the effect of exenatide and metformin on treatment of newly diagnosed type 2 diabetes.Methods 68 patients with newly diagnosed type 2 diabetes were randomly divided into two groups: metformin group (35 patients) and exenatide group (33 patients) and were treated for 12 weeks. The changes in FBG, 2 h PG, HbA1c, CHO, TG, LDL, BMI, MAGE, LAGE and MPPGE were observed in two groups.Results After 12 weeks of treatment, in two groups the levels of FBG, 2 h PG, HbA1c, MAGE, LAGE and MPPGE showed significant decrease (P<0.05), and no significant difference was observed. After treatment,TG was significantly lower than before treatment in the two groups (P<0.05), TG was (1.88±0.57) mmol/L in metformin group and (1.58±0.21) mmol/L in exenatide group; compared with metformin group, in the exenatide group it decreased more significantly (P<0.05). In exenatide group, body mass index (BMI) was (25.14±2.21) kg/m2 before treatment and (23.16±1.46) kg/m2 after treatment, BMI was significantly decreased after treatment (P<0.05).Conclusions In patients with newly diagnosed type 2 diabetes, exenatide and metformin can remarkably control blood glucose. The effect of exenatide on body weight and TG are better than that of metformin.
Key words
exenatide /
metformin /
type 2 diabetes /
glucose fluctuation
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