Effectiveness of Low-molecular-weight heparin in combination with intermittent pneumatic compression against deep venous thrombosis following arthroplasty

BAI Bo; ZHOU Pu; CHEN Guodong; NIU Zengguang

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Medical Journal of the Chinese People Armed Police Forces ›› 2017, Vol. 28 ›› Issue (10) : 1031-1034.

Effectiveness of Low-molecular-weight heparin in combination with intermittent pneumatic compression against deep venous thrombosis following arthroplasty

BAI Bo¹, ZHOU Pu², CHEN Guodong¹, NIU Zengguang¹

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Abstract

Objective To investigate the effectiveness of intermittent pneumatic compression (IPC) device combined with low molecular weight heparin (LMWH) for the prevention of deep venous thrombosis(DVT) after joint replacement surgery.Methods 80 cases with hip or knee joint peripheral fractures and artificial joint replacements who were admitted to our hospital between January 2015 and January 2016 were randomly divided into two groups. The observation group was treated with low molecular heparin by subcutaneous injection and intermittent pneumatic compression to both lower limbs alternately, while the control group was treated with low molecular heparin alone after operation. The clinical symptoms of venous thromboembolism were observeded, deep venous thrombosis of both lower limbs examined by colour duplex ultrasonography ,and platelet count and blood coagulation were monitored after operation to check the presence of DVT.Results The incidence rates of venous thromboembolism in lower limbs after operation were significantly lower in the observation group than in the control group,so was the amount of bleeding. Pulmonary embolism did not occur in any of the cases. International normalized ratio( INR) did not exceed 2.5 and platelet count did not decrease.Conclusions LMWH in combination with IPC can significantly reduce the incidence of VTE after hip or knee surgery, and is quite safe.

Key words

arthroplasty / replacement / venous thrombosis / heparin / low-molecular-weight / intermittent pneumatic compression

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BAI Bo, ZHOU Pu, CHEN Guodong, NIU Zengguang. Effectiveness of Low-molecular-weight heparin in combination with intermittent pneumatic compression against deep venous thrombosis following arthroplasty[J]. Medical Journal of the Chinese People Armed Police Forces. 2017, 28(10): 1031-1034

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