Objective To analyze the changes of serum fibroblast growth factor -23 (FGF-23) and inflammatory factors of secondary hyperparathyroidism (SHPT) patients who had undergone total parathyroidectomy, and explore the significance of these changes.Methods Forty SHPT patients treated with T-PTX between January 2011 and January 2013 in the Department of Nephrology, Armed Police General Hospital, were enrolled in this study. Each patient was given hemodialysis. Serum FGF -23, parathyroid hormone (PTH), calcium(Ca), phosphorus (P) and high sensitivity reactive protein (hsCRP) obtained during the preoperative, postoperative and follow-up periods were collected and compared.Results (1)Serum levels of FGF-23, PTH, Ca, P, and hsCRP decreased significantly one day, one month, three months and 6 months after PTX (P＜0.05). (2)Levels of serum hsCRP decreased one day after PTX, but not significantly. Serum hsCRP was (20.31±8.56)mg/L before PTX, and was (11.72±5.21) mg/L, (2.64±1.32) mg/L, and (2.16±1.08)mg/L respectively 1 month, 3 months, and 6 months after PTX (P＜0.05).Conclusions T-PTX can effectively reduce the levels of serum FGF-23, PTH and inflammatory factors, correct the disturbance of Ca and P metabolism, and reduce the incidence of long-term cardiovascular events and bone metabolism diseases.
Key words
secondary hyperparathyroidism /
serum fibroblast growth factor -23 /
T-PTX
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