Experimental study of autogenous vein patches for repair of defective tracheal membranous walls

CAO Lei; LI Shanqing; CAO Zhili

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Medical Journal of the Chinese People Armed Police Forces ›› 2017, Vol. 28 ›› Issue (12) : 1232-1235.

ORIGINAL ARTICLES

Experimental study of autogenous vein patches for repair of defective tracheal membranous walls

CAO Lei, LI Shanqing, CAO Zhili

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Abstract

Objective To investigate the feasibility of vein patch grafts being used to repair defective tracheal membranous walls.Methods The right jugular veins of eight adults dogs were harvested though midline cervical incisions and used as patch grafts. Each cervical trachea was exposed and a full-thickness lesion (2 cm×2 cm) was created in the cervical tracheal membranous wall by resecting part of the trachea at the forth ring below the cricoid cartilage. The defect was repaired by grafting a vein patch to the posterior surface of the injured part.Results All the eight dogs survived without complications until euthanasia 6 months later. Bronchoscopic examination demonstrated adequate tracheal patency with no inspiratory or expiratory collapse. The experimental dogs were killed 6 months after operation, and the constrictive ratio of the cross-sectional area of the most stenotic site to that of the third tracheal ring below the membranous patch was 1.07±0.04, suggesting that there was no obvious stenosis in the tracheal lumen. Histological examination revealed neoepithelium on the surfaces of all the patch grafts.Conclusions Our Results indicate that jugular vein patch grafts can be effectively and safely used to repair tracheal membranous wall lesions.

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vein patch grafts / defective tracheal membranous walls / repair

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CAO Lei, LI Shanqing, CAO Zhili. Experimental study of autogenous vein patches for repair of defective tracheal membranous walls[J]. Medical Journal of the Chinese People Armed Police Forces. 2017, 28(12): 1232-1235

References

[1] Steger V,Hampel M,Trick I, et al. Clinical tracheal replacement:transplantation, bioprostheses and artificial grafts[J]. Expert Rev Med Devices,2008, 5(5):605-612.
[2] Macchiarini P, Jungebluth P, Go T, et al. Clinical transplantation of a tissue-engineered airway [J]. Lancet,2008, 372(9655):2023–2030.
[3] Hamilton N, Bullock A J, Macneil S, et al. Tissue engineering airway mucosa: a systematic review[J]. Laryngoscope,2014, 124(4):961-968.
[4] Gonfiotti A,Jaus M O,Barale D, et al.The first tissue-engineered airway transplantation: 5-year follow-up results[J].Lancet,2014,383(9913):238-244
[5] Klepetko W, Marta G M,Wisser W, et al. Heterotopic tracheal transplantation with omentum wrapping in the abdominal position preserves functional and structural integrity of a human tracheal allograft[J]. J Thorac Cardiovasc Surg, 2004, 127(3): 862-867.
[6] Shi H, Xu H, Lu D, et al. Animal models of tracheal allotransplantation using vitrified cryopreservation[J]. J Thorac Cardiovasc Surg,2009 ,138(5):1222-1226
[7] Iyikesici T, Tuncozgur B, Sanli M, et al. Two-piece cryopreserved tracheal allotransplantation: an experimental study [J]. Eur J Cardiothorac Surg, 2009, 36(4): 722-726.
[8] Huang X, Yan X, Zhang Z, et al. Seeding of recipient-originated epithelial cells attenuates epithelial to mesenchymal transition in rat tracheal allotransplantation [J]. Otolaryngol Head Neck Surg,2015, 152(6): 1068-1074.
[9] Pfitzmann R, Kaiser D, Weidemann H, et al. Plastic reconstruction of an extended corrosive injury of the posterior tracheal wall with an autologous esophageal patch[J]. Eur J Cardiothorac Surg,2003,24(3):463-465.
[10] Fabre D, Singhal S, De Montpreville V, et al. Composite cervical skin and cartilage flap provides a novel large airway substitute after long-segment tracheal resection[J]. J Thorac Cardiovasc Surg, 2009, 138(1): 32-39.
[11] Hazekamp M G, Koolbergen D R, Kersten J, et al. Pediatric tracheal reconstruction with pericardial patch and strips of autologous cartilage[J]. Eur J Cardiothorac Surg,2009, 36(2): 344-351.
[12] Anoosh F, Hodjati H, Dehghani S, et al.Tracheal replacement by autogenous aorta[J]. J Cardiothorac Surg, 2009,4: 23.
[13] 李文,杨柳,袁莉清, 等. 带蒂胸锁乳突肌锁骨骨膜皮瓣修复喉气管缺损的初步研究[J]. 临床耳鼻咽喉头颈外科杂志, 2015, 29(2): 117-120.
[14] Fabre D, Kolb F, Fadel E, et al. Successful tracheal replacement in humans using autologous tissues: an 8-year experience[J]. Annals Thorac Surg, 2013, 96(4): 1146-1155.
[15] Wurtz A, Hysi I, Kipnis E, et al. Tracheal reconstruction with a composite graft: fascial flap-wrapped allogenic aorta with external cartilage-ring support [J]. Int Cardiovasc Thoracic Surg,2013, 16(1): 37.
[16] Martinod E, Seguin A, Radu D M, et al. Airway transplantation: a challenge for regenerative medicine[J]. Eur J Med Res,2013,18(1):25.