Objective To explore the significance of increased levels of plasma D-dimer (D-D) and relevant white blood cell (WBC) variation for patients with brain trauma.Methods Medical data on two hundred and forty-six cases of patients with craniocerebral trauma was retrospectively analyzed, while another thirty-five healthy people were randomly selected as control. D-D levels and whole blood cells were tested for the first time after hospitalization. Abnormally elevated D-D levels and correlated changes of WBC parameters were statistically analyzed.Results For patients with traumatic brain injury, the D-D concentration was (8.20±5.93) mg/L, WBC(12.54±3.59)×10⁹/L, NEU%(89.97±9.40)% and NEU# was (10.82±3.22)×10⁹/L, which were significantly higher than in the healthy control group(0.19±0.12) mg/L, (6.15±0.92)×10⁹/L, (60.28±9.05)% and (4.36±0.11)×10⁹/L (P<0.01) respectively. The degree of elevated D-D was positively correlated with WBC, NEU% and NEU# in blood cell parameters (P<0.01), but negatively correlated with LYM% and LYM# (P<0.05). The difference was statistically significant.Conclusions The degree of D-D and WBC of patients are higher than those of healthy people. The degree of elevated D-D is positively correlated with WBC for patients with brain trauma.