Expression of PR-SET7 in esophageal carcinoma and its correlation with clinical features and PCNA index

ZHENG Jian; MA Shikun; and CHEN Jian

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Medical Journal of the Chinese People Armed Police Forces ›› 2017, Vol. 28 ›› Issue (2) : 161-164.

ORIGINAL ARTICLES

Expression of PR-SET7 in esophageal carcinoma and its correlation with clinical features and PCNA index

ZHENG Jian,MA Shikun,and CHEN Jian

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Abstract

Objective To investigate the expression of lysine methyltransferase(KMT) PR-SET7 in esophageal carcinoma and its relationship with clinical features and proliferating cell nuclear antigen(PCNA).Methods Immunohistochemistry was used to detect the PR-SET7 and PCNA expressions in esophageal cancer tissues and adjacent normal tissues of 32 cases between June 2010 and February 2011. The correlations between the expression of PR-SET7 and patients’ gender, age, degree of carcinoma tissue differentiation, TNM stages, lymph node metastasis and proliferation of tumor cells were analyzed.Results Immunohistochemistry Results showed that PR-SET7 and PCNA were mainly expressed in nuclear. The expression of PR-SET7 and PCNA in cancerous tissues was significantly stronger than in adjacent tissues. The high expression rate of PR-SET7 was 81.25%, but the expression was mostly low in adjacent tissues, where the high expression rate was 15.62%(P<0.01).PCNA index in cancer tissues was 68.12±16.03, normal tissues was 38.22±20.56,both comparative difference was statistically significint (P<0.05).PR-SET7 protein levels in patients with esophagus carcinoma were correlated with invasive depth and lymph node metastasis (P<0.05) rather than with age or gender (P>0.05).There was a significant correlation between the expression of PR-SET7 and PCNA index (r_s=0.551,P=0.001).Conclusions There is an abnormal expression of PR-SET7 and PCNA during the development and progression of esophageal carcinoma. The expression level may be related to tumor progression, metastasis and prognosis. There is a significant correlation between PR-SET7 and PCNA overexpression in cancer tissues, which is of significance for exploration of the mechanism.

Key words

PR-SET7 / PCNA / esophageal carcinoma / expression / prognosis

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ZHENG Jian,MA Shikun,and CHEN Jian. Expression of PR-SET7 in esophageal carcinoma and its correlation with clinical features and PCNA index[J]. Medical Journal of the Chinese People Armed Police Forces. 2017, 28(2): 161-164

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