Objective To investigate the effect of rhIL-12 on the hemopoietic function, immune function, radiation protection function and tumor evaluation indexes in the tumor radiotherapy group and advanced palliative treatment group.Methods There were 53 cases of tumor patients treated with Cyber knife in treatment group, including 19 cases of 150 ng/kg, 24 cases of 250 ng/kg, and 10 cases of control. There were 47 cases of cancer patients in advanced palliative treatment group, including 20 cases of 150 ng/kg, 21 cases of 250 ng/kg, and 6 cases of control. rhIL-12 was given on the day of treatment and the therapeutic effect was observed for 4 consecutive weeks. The dose-effect relationship was studied.Results RhIL-12 could significantly inhibit the decline of blood cells, prevent immune disorders and reduce radiation injury in the two groups. After the first-dose, there were 19 cases of fever, 9 cases of discomfor, 2 cases of slight changes in serum aminotransferase and bilirubin. There was no other adverse event.Conclusions rhIL-12 may be a safe and effective drug for cancer prevention and treatment in clinical practice.
Key words
rhIL-12 /
radiosurgery /
advanced tumor /
research
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