Expression and clinical significance of retinal dehydrogenase 1(ALDH1A1 )in gallbladder carcinoma by tissue microarray

HUANG Hailin; CHEN Chao; GAN Quan; and DU Zheming

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Medical Journal of the Chinese People Armed Police Forces ›› 2017, Vol. 28 ›› Issue (4) : 337-339.

ORIGINAL ARTICLES

Expression and clinical significance of retinal dehydrogenase 1(ALDH1A1 )in gallbladder carcinoma by tissue microarray

HUANG Hailin, CHEN Chao, GAN Quan, and DU Zheming

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Abstract

Objective To explore the expression and clinical significance of retinal dehydrogenase 1(ALDH1A1) in gallbladder carcinoma.Methods The expressions of ALDH1A1 were detected in 59 specimens of gallbladder carcinoma tissues,7 specimens of adjacent non-tumor tissues and 6 specimens of chronic cholecystitis tissues by tissue microarray technique and immunohistochemistry.Results In 7 specimens of adjacent non-tumor tissues and 6 specimens of chronic cholecystitis tissues, there was a positive expression of ALDH1A1. The expression of ALDH1A1 was not detected or weakly positive in 59 gallbladder carcinoma tissue specimens and the positive rate was 62.7%(37/59). The positive rate of ALDH1A1 in tissue specimens of gallbladder carcinoma was significantly lower than the expression in the adjacent non-tumor tissues or chronic cholecystitis tissues(P<0.05). ALDH1A1 was negatively correlated with disease progression and tissue differentiation, and there was significant difference in levels of expression (P<0.05).Conclusions The expression of ALDH1A1 in gallbladder carcinoma tissues is negatively correlated with the progression of disease and tissue differentiation.

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gallbladder carcinoma / tissue microarray technique / ALDH1A1

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HUANG Hailin, CHEN Chao, GAN Quan, and DU Zheming. Expression and clinical significance of retinal dehydrogenase 1(ALDH1A1 )in gallbladder carcinoma by tissue microarray[J]. Medical Journal of the Chinese People Armed Police Forces. 2017, 28(4): 337-339

References

[1] de Groen P C, Gores G J, LaRusso N F, et al. Biliary tract cancers [J]. N Engl J Med, 1999, 341(10): 1368-1378.
[2] Carriaga M, Henson D E. Liver, gallbladder, extrahepatic bile ducts, and pancreas [J]. Cancer,1995, 75(1): 171-190.
[3] Henson D, Albores-Saavedra J, Corle D. Carcinoma of the gallbladder: histologic types, stage of disease, grade, and survival rates [J]. Cancer, 1992,70(6): 1493-1497.
[4] Fong Y, Jarnagin W, Blumgart L H. Gallbladder cancer: comparism of patients presenting initially for definitive operation with those presenting after prior noncurative intervention [J]. Ann Surg, 2000, 232(5):557-569.
[5] Rosenmuller M, Haapamaki M M, Nordin P, et al. Cholecystectomy in Sweden 2000-2003: a nationwide study on procedures, patient characteristics, and mortality [J]. BMC Gastroenterol, 2007, 7(1): 35.[6] Kozak L J, DeFrances C J, Hall M J. National hospital discharge survey: 2004 annual summary with detailed diagnosis and procedure data [J]. Vital Health Stat 13, 2006, 162 (11):1-209.
[7] Chan C P, Chang H C, Chen Y L, et al. A 10-year experience of unsuspected gallbladder cancer after laparoscopic cholecystectomy [J]. Int Surg,2003,88(3):175-179.
[8] Budin S B, Othman F, Louis S R, et al. Effect of alpha lipoic acid on oxidative stress and vascular wall of diabetic rats[J]. Rom J Morphol Embryol, 2009, 50(1): 23-30.
[9] Daiss N, Lobo G, Gonzalez M. Changes in postharvest quality of Swiss chard grown using 3 organic preharvest treatments[J]. J Food Sci, 2008, 73(6): S314-S320.
[10] Manicassamy S, Ravindran R, Deng Jiusheng, et al. Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity [J]. Nat Med, 2009, 15(4): 401-409.
[11] Markert S, Lassmann S, Gabriel B, et al. Alpha-folate receptor expression in epithelial ovarian carcinoma and non-neoplastic ovarian tissue [J]. Anticancer Res, 2008, 28(6A): 3567-3572.