Clinicopathologic features of papillary thyroid carcinoma  complicated with asymptomatic parathyroid adenoma

YANG Bo; LIU Zhiying; WEN Xiaoju; and LI Ruiguang

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Medical Journal of the Chinese People Armed Police Forces ›› 2017, Vol. 28 ›› Issue (4) : 340-343.

ORIGINAL ARTICLES

Clinicopathologic features of papillary thyroid carcinoma complicated with asymptomatic parathyroid adenoma

YANG Bo¹,LIU Zhiying²,WEN Xiaoju¹,and LI Ruiguang¹

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Abstract

Objective To improve the diagnosis of parathyroid adenoma by exploring the clinic and pathological manifestations of papillary thyroid carcinoma complicated with asymptomatic parathyroid adenoma.Methods The clinical data and histopathological features of twelve patients who had been diagnosed with PTC and PA in the Affiliated Tumor Hospital to Xinjiang Medical University between January 2005 and December 2014 were retrospectively analyzed.Results Two of the twelve cases suffered from hypercalcemia, increased serum parathyroid hormone(PTH) and hypophosphatemia. Histological examination of PA showed that tumor cells consisted of principal cells and eosinophilic cytoplasm. The tumor cells were nest-like, lamellar or cystic. All of them had intact fibrous capsules. Mitotic figures were rarely encountered and tumor necrosis was absent. Immunohistochemical study showed that the tumor cells in PA were positive(12/12) for CK19, chromogranin A and parathyroid hormone, but were negative for thyroglbulin, TTF-1 and calcitonin. The Ki-67 index was less than 3%.Conclusions The concurrence of PTC and PA is rare.For the coexistence of complex lesions of PA and PTC, preoperative imaging diagnosis is more difficult. Careful preoperative examination is required to rule out the coexistence of the two diseases.

Key words

parathyroid adenoma / papillary thyroid carcinoma / asymptomatic

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YANG Bo,LIU Zhiying,WEN Xiaoju,and LI Ruiguang. Clinicopathologic features of papillary thyroid carcinoma complicated with asymptomatic parathyroid adenoma[J]. Medical Journal of the Chinese People Armed Police Forces. 2017, 28(4): 340-343

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