Influence of lipid microsphere alprostadil combined with edaravone onneurological function and serum S100B level of acute ischemic stroke patients

AN Zhanjun; XU Lixia; and CAO Jiewei

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Medical Journal of the Chinese People Armed Police Forces ›› 2017, Vol. 28 ›› Issue (5) : 475-477.

Influence of lipid microsphere alprostadil combined with edaravone onneurological function and serum S100B level of acute ischemic stroke patients

AN Zhanjun¹,XU Lixia²,and CAO Jiewei¹

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Abstract

Objective To investigate the influence of lipid microsphere alprostadil combined with edaravone on the neurological function and serum S100B level of patients with acute cerebral infarction.Methods Between June 2014 and June 2016, sixty patients with acute cerebral infarction were enrolled and randomly and equally divided into the combined group (lipid microsphere alprostadil and edaravone) and the control group (edaravone alone). All the patients received brain MRI examinations(DWI) before treatment, and NIHSS and serum S100B tests before treatment as well as at day 3, 7 and 14 during treatment. The changes of NIHSS and serum S100B levels were compared between the two groups at different time points.Results NIHSS and serum S100B levels of the combined group at day 3, 7 and 14 during treatment were significantly lower than those of the control group(P<0.01). There were two cases of disease progression in the control group, but with no cases of adverse reactions. In the combined group, there was one case of progression, two cases of headache, and one patient who appeared red-faced and felt slightly swollen.Conclusions Lipid microsphere alprostadil combined with edaravone can improve clinical efficacy and alleviate brain damage in patients with acute ischemic stroke.

Key words

acute cerebral infarction / lipid microsphere alprostadil / edaravone / NIHSS / serum S100B

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AN Zhanjun,XU Lixia,and CAO Jiewei. Influence of lipid microsphere alprostadil combined with edaravone onneurological function and serum S100B level of acute ischemic stroke patients[J]. Medical Journal of the Chinese People Armed Police Forces. 2017, 28(5): 475-477

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