Objective To compare the effects of different purification methods on elements related to rental osteopathy.Methods Sixty-four patients who had undergone blood purification for six months and had been diagnosed with rental osteopathy at our center were randomly and equally divided into four groups: HD group, HFHD (once a week) group, HD+HDF(once a week) group and HD+HP(once a week) group to compare the changes in the levels of Ca,P, PTH, ALP and β2-MG in each group before treatment and 24 weeks after treatment. Calcium-phosphorus product(Ca×P)was also calculated.Results After treatment, levels of P,ALP,PTH,β2-MG and the product of Ca×P(P<0.05) in the HFHD group HD+HDF group and HD+HP group were significantly decreased. The ability to clean up P(1.91±0.19)mmol/L, β2-MG(11.32±2.61)mg/L and PTH(347.21±152.05)pg/ml in the HD+HDF group was improved compared to P(1.98±0.41)mmol/L, β2-MG(17.09±5.06)mg/L and PTH(471.98±123.02)pg/ml in the HFHD group. Furthermore, the same ability of the HD+HP group was better than that of the HFHD group(P<0.05).However, there was no significant difference between HD+HDF group and HD+HP group. Meanwhile, the levels of P,Ca×P,PTH and β2-MG in HD group did not decrease after treatment. The level of Ca remained unchanged after treatment.Conclusions P, PTH and β2-MG in the HFHD group, HD+HDF group and HD+HP group can be better cleaned up than in the HD group.
Key words
rental osteopathy /
hemodialysis /
hemoperfusion /
parathormone /
β2-microglobuhn
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References
[1] 漆映辉,倪兆慧,曲晓璐,等. 不同血液净化技术的联合应用对维持性血液透析患者矿物质和骨异常的影响[J].中国血液净化,2016,15(2):72-76.
[2] Souqiyyeh M Z,haheen F A. Survey of attitudes of physicians toward the current evaluation and treatment of chronic kidney disease-mineral and bone disorder(CKD-MBD) [J].Saudi J Kidney Dis Transpl,2010,21(1):93.
[3] Abe M,Okada K,Soma M. Mineral metabolic abnormal-ities and mortality in dialysis patients[J].Nutrients,2013,5(3):1002-1023.
[4] Goodman W G,Goldin J,Kuizon B D,et al.Coronary-artery calcification in young adults with end stage renal disease who are undergoing dialysi[J].N Engl J Med,2000,342(20):1478-1483.
[5] Eddington H,Kalra P A.The association of chronic kidney disease-mineral bone disorder and cardiovascular risk[J].J Ren Care,2010,36 (Suppl I):61-67.
[6] Floege J,Ehlerding G.β2-microglobuhn -associated amyloidosis[J].Nephron,1996,72(1):9-26.
[7] 叶朝阳,徐 涛,毛志国,等.高通透量血液透析对慢性肾衰患者甲状旁腺素和β2-微球蛋白的清除作用[J].第二军医大学学报,2003,24(3):318-320.
[8] 史应进,王彩丽,董玉红,等.不同血液净化方法对慢性肾功能衰竭维持性血液透析患者血清甲状旁腺素和β2-微球蛋白的影响[J].包头医学院学报, 2011,27(2):44-47.
[9] 谢红浪,季大玺. On-line hemodiafiltration技术和临床应用[J].肾脏病与透析肾移植杂志, 2005,14(4):377-381.
[10] 安书强,杨 倩,史长生.血液灌流串联血液透析滤过改善肾性骨营养不良效果研究[J].武警后勤学院学报(医学版),2013,22(6):468-472.
[11] 赵云艽, 邱国萍.血液灌流联合血液透析治疗继发性甲状旁腺功能亢进的疗效观察[J].中国当代医药, 2012, 19(3):38-39.
[12] 焦春红,高 丽,周 洁,等.高通量透析器对高磷血症的疗效观察[J].天津医药,2013,41(1):33-36.
[13] 王义涛,江菲菲.常规血液透析、高通量血液透析和血液透析滤过对血清甲状旁腺激( PTH) 的清除效果比较[J].医学检验与临床,2010,21(4):74-76.
[14] Dost P,Ten Cate W J,Wiemann M.Osteoblast-like cell cultures from human stapes[J].Acta Otolaryngol,2002,122(8):836-840.
[15] 贾艳丽,刘惠兰.甲状旁腺素及骨转运指标的测定在维持性血液透析患者肾性骨病诊断中的意义[J].首都医科大学学报,2010,12(6):803-807.
[16] 崔爱民,张自琴,蔺锡侯.原发性甲状旁腺功能亢进术后血清ALP的动态变化特点及意义[J].中国骨质疏松杂志,2008,10(14):738-744.
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