Relationships between EZH2 expression and EGFR mutation in lung adenocarcinoma

WANG  Yuxin; ZHAO  Tianmiao; BAO  Fang; HAN  Yanhua; KONG Lili; and SUN Mei

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Medical Journal of the Chinese People Armed Police Forces ›› 2017, Vol. 28 ›› Issue (6) : 587-590.

ORIGINAL ARTICLES

Relationships between EZH2 expression and EGFR mutation in lung adenocarcinoma

WANG Yuxin¹, ZHAO Tianmiao²,BAO Fang³,HAN Yanhua⁴,KONG Lili⁵,and SUN Mei⁵

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Abstract

Objective To explore the expression of EZH2 in lung adenocarcinoma and its associations with EGFR mutation.Methods Immunohistochemistry was used to examine the expression of EZH2 while EGFR mutation was detected with real-time fluorescence PCR.Results The expression of EZH2 in lung adenocarcinom(84.00%) was significantly higher than in normal lung tissues(12.00%) and in benign lung disease(11.11%) (P<0.05). EZH2 expression was related to tumor size, histological subtypes of adenocarcinoma and T stage(P<0.05), but not to EGFR mutation.Conclusion EZH2 may be involved in lung oncogenesis and development. The expression of EZH2 is not linked to EGFR mutation. It can be a new target for the treatment of lung adenocarcinoma.

Key words

lung adenocarcinoma / EZH2 / EGFR mutation

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WANG Yuxin, ZHAO Tianmiao,BAO Fang,HAN Yanhua,KONG Lili,and SUN Mei. Relationships between EZH2 expression and EGFR mutation in lung adenocarcinoma[J]. Medical Journal of the Chinese People Armed Police Forces. 2017, 28(6): 587-590

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