Significance of TMPO forprognosis of patients with lung cancer

XIONG Zhi

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Medical Journal of the Chinese People Armed Police Forces ›› 2017, Vol. 28 ›› Issue (8) : 764-768.

ORIGINAL ARTICLES

Significance of TMPO forprognosis of patients with lung cancer

XIONG Zhi

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Abstract

Objective To clarify the relationships between TMPO gene expression and clinical prognosis of lung cancer.Methods NCBI datasets were collected while expression profiles and clinical information were analyzed to characterize the expressions of TMPO gene in lung cancer patients and adjacent normal lung tissues. The correlations between TMPO expressions and TNM staging, progression free survival and overall survival of lung cancer patients were studied. Gene set enrichment analysis was applied to investigate the exact mechanisms related to the expression of TMPO and the proliferation of lung cancer cells.Results The level of TMPO expression was higher in lung cancer patients than that in normal controls (P<0.0001). Lung cancer patients with higher expressions of TMPO were associated with better TNM staging(P<0.0001, P<0.0001, P=0.031), progression free survival(P<0.0001), and overall survival(P<0.0001)compared with TMPO low expression cohort. The result of GSEA indicated that TMPO might promote the proliferation of lung cancer cells involving DNA repair, MYC signaling, mitotic spindle, G₂M checkpoint, spermatogenesis, E₂F signaling and mTORC1 signaling.Conclusions Our Results suggest that TMPO might be an independent risk factor for lung cancer patients.

Key words

TMPO / lung cancer / clinical prognosis

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XIONG Zhi. Significance of TMPO forprognosis of patients with lung cancer[J]. Medical Journal of the Chinese People Armed Police Forces. 2017, 28(8): 764-768

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