Comparison of antiplatelet effects of ticagrelor and clopidogrel in patients with acute coronary syndrome

LI Xiaohong; YANG Ming; HAN Ling; CHEN Xin; CHEN Ping; and HU Wenze

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Medical Journal of the Chinese People Armed Police Forces ›› 2018, Vol. 29 ›› Issue (1) : 14-16.

ORIGINAL ARTICLES

Comparison of antiplatelet effects of ticagrelor and clopidogrel in patients with acute coronary syndrome

LI Xiaohong, YANG Ming, HAN Ling, CHEN Xin, CHEN Ping, and HU Wenze

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Abstract

Objective To investigate the therapeutic effect of ticagrelor and clopidogrel in patients with acute coronary syndrome(ACS).Methods Sixty-eight patients with ACS who were admitted to our department were enrolled in this study. All the patients were treated with percutaneous coronary intervention (PCI)before they were randomly divided into two groups: ticagrelor group and clopidogrel group(n=34 in each). After seven days, thrombelastography (TEG )was used to compare the platelet inhibition rate between the two groups.After two months of follow-up, the major adverse events were compared between the two groups.Results After seven days of treatment, the platelet inhibition rate induced by ADP in ticagrelor group increased significantly(76.15±12.88)% vs (51.08±8.32)% compared with clopidogrel group.After two months of follow-up, there was one case of acute myocardial infarction, one death due to cardiovascular diseases and one case of gastrointestinal bleeding in clopidogrel group. One patient in ticagrelor group had medication suspended because of serious dyspnea.Conclusions For ACS patients who have received PCI, ticagrelor has a better anti platelet aggregation effect than clopidogrel, and it has proved to be safe.

Key words

acute coronary syndrome / ticagrelor / clopidogrel / thrombelastography / platelet inhibition rate

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LI Xiaohong, YANG Ming, HAN Ling, CHEN Xin, CHEN Ping, and HU Wenze. Comparison of antiplatelet effects of ticagrelor and clopidogrel in patients with acute coronary syndrome[J]. Medical Journal of the Chinese People Armed Police Forces. 2018, 29(1): 14-16

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