Objective To investigate the efficacy of flurbiprofenaxetil combined with dezocine during gallbladder removal surgery. Methods One hundred patients of ASAⅠ－Ⅱ undergoing gallbladder removal surgery were randomly assigned to four groups(n=25):flurbiprofenaxetil group, dezocine group, flurbiprofenaxetil combined with dezocine group and control group. Before anesthesia induction, flurbiprofenaxetil 1.5 mg/kg was injected intravenously in flurbiprofenaxetil group， dezocine 0.15 mg/kg in dezocine group, flurbiprofenaxetil 1.5 mg/kg combined with dezocine 0.15 mg/kg in flurbiprofenaxetil combined with dezocine group,while an equal volume of saline was given in control group. The extubation time and visual analgesia scale scores were recorded at 2,4,6,12 and 24 h after operation.The incidence of adverse reactions was recorded within 24 h. Results The VAS scores at 2,4,and 6 h were lower in flurbiprofenaxetil group and dezocine group than in control group (P<0.05), and were lower in flurbiprofenaxetil combined with dezocine group than in control group at 2,4,6 and 12 h (P<0.05). Compared with control group, the incidence of complications was increased in the other three groups (P<0.05). Compared with flurbiprofenaxetil combined with dezocine group, the incidence of dizziness and somnolence was decreased in flurbiprofenaxetil group(P<0.05), and that of nausea was decreased in dezocine group(P<0.05). Conclusions Flurbiprofenaxetil (1.5 mg/kg) combined with dezocine has (0.15 mg/kg）better analgesic effect, but the adverse reaction rate can increase in patients during gallbladder removal surgery.
Key words
flurbiprofen /
dezocine /
cholecystotomy /
gallbladder removal surgery
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