Effect of Ginkgo biloba extract on pharmacokinetics of clopidogrel and its mechanism

WANG Dongyin; HUANG Qiuling; CHEN Lifeng; and CHEN Zhimin

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Medical Journal of the Chinese People Armed Police Forces ›› 2018, Vol. 29 ›› Issue (12) : 1133-1137.

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Effect of Ginkgo biloba extract on pharmacokinetics of clopidogrel and its mechanism

WANG Dongyin, HUANG Qiuling, CHEN Lifeng, and CHEN Zhimin

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Abstract

Objective To study the effects of Ginkgo biloba extract on pharmacokinetics of clopidogrel and its mechanism.Methods Fourteen healthy male volunteers took a single 100-mg oral dose of clopidogrel either alone or after pretreatment with 240 mg Ginkgo biloba extract daily for 14 days. On day 14, a single 100-mg oral dose of clopidogrel was administered. Plasma SR26334 concentrations of clopidogrel from zero to 24 h were measured by high-performance liquid chromatography.Results AUC_(0-t)(3192.3±45.035), AUC_(0-∞)(3343.017±43.829) and C_max(340.988±11.257) of SR26334 in the combination group was significantly higher than that of the single-drug group (P<0.05).Conclusions Ginkgo biloba extractcan increase the bioavailability and absorption of clopidogrel. The mechanism may be related to Ginkgo biloba’s significant inhibition of P-glycoprotein.

Key words

Ginkgo biloba / clopidogrel / SR-26334 / pharmacokinetics

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WANG Dongyin, HUANG Qiuling, CHEN Lifeng, and CHEN Zhimin. Effect of Ginkgo biloba extract on pharmacokinetics of clopidogrel and its mechanism[J]. Medical Journal of the Chinese People Armed Police Forces. 2018, 29(12): 1133-1137

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