Objective To investigate the expression and clinical significance of Jagged-1 protein in hepatitis B virus(HBV)-related hepatocellular carcinoma. Methods Between November 2008 and June 2012,a total of 110 adult patients with HBV-related HCC undergoing hepatectomy in our center were enrolled and tissue microarrays were used to detect the level of Jagged-1 expression before retrospective analysis was made to investigate the relationships between Jagged-1 expression and the clinical characteristics and prognosis.Results The Results of tissue microarrays showed that the rate of Jagged-1 over-expression was significantly higher in HCC tissues(44.5%) than that in paired nocancerous tissues(22.3%;χ2=12.16,P<0.0001).Over-expression of Jagged-1 protein was significantly correlated with microvascular invasion in HCC samples. Kaplan-Meier survival analysis in both cohorts showed that patients with over-expression of Jagged-1 had lower 1, 3, 5-year overall survival rate (87.5%, 64.1%, 46.5% vs 96.7%, 84.5%, 66.9%in over- or low-expression groups,P=0.0139) .Conclusions Increased Jagged-1 expression levels are closely associated with microvascular invasion and poor prognosis for HBV-related HCC patients.
Key words
hepatitis B virus /
hepatocellular carcinoma /
Jagged-1
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