The clinical study of hyperbaric oxygen in the treatment of neonatal hypoxic ischemic encephalopathy

LI Na; LV Yan; MENG Xiangen; GUO Dazhi; PAN Shuyi

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Medical Journal of the Chinese People Armed Police Forces ›› 2018, Vol. 29 ›› Issue (3) : 282-286.

ORIGINAL ARTICLES

The clinical study of hyperbaric oxygen in the treatment of neonatal hypoxic ischemic encephalopathy

LI Na, LV Yan, MENG Xiangen, GUO Dazhi, PAN Shuyi

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Abstract

Objective To investigate the clinical effect of hyperbaric oxygen in the treatment of neonatal hypoxic ischemic encephalopathy.Methods Between January 2013 and February 2017, 130 cases of neonatal hypoxic ischemic encephalopathy were selected as subjects, who were randomly divided into control group and observation group with 65 cases in each. The control group was given routine symptomatic treatment, while the observation group was additionally given hyperbaric oxygen therapy. Both groups were observed for three months.Results After treatment, the total effective rates in the observation group and the control group were 98.5% and 81.5%, respectively.After treatment, the MMSE scores in the observation group and the control group were 89.45±5.39 points and 78.20±6.14 points, compared with 65.23±8.14 points and 65.11±7.89 points before treatment (P<0.05).The levels of serum CK, LDH and CK were significantly lower after treatment in the two groups (P<0.05), and the indexes in the observation group were significantly lower after treatment than those in the control group (P<0.05).The NOX2 gray ratio and ROS in the two groups were significantly lower after treatment.The NOX2 gray ratio (0.37±0.06) in the observation group was significantly lower after treatment than in the control group (0.42±0.09) (P<0.05). ROS (518.85±54.48) U/ml in the observation group was also significantly lower than in the control group (551.28±69.93) U/ml (P<0.05).Conclusions Hyperbaric oxygen, when used in the treatment of neonatal hypoxic ischemic encephalopathy, can improve myocardial function while inhibiting oxidative stress, thus improving the therapeutic effect and promoting cognitive function, so it has good applicability.

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hyperbaric oxygen / neonatal hypoxic ischemic encephalopathy / myocardial function / oxidative stress

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LI Na, LV Yan, MENG Xiangen, GUO Dazhi, PAN Shuyi. The clinical study of hyperbaric oxygen in the treatment of neonatal hypoxic ischemic encephalopathy[J]. Medical Journal of the Chinese People Armed Police Forces. 2018, 29(3): 282-286

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