Clinical Effect of levosimendan in the treatment of refractory heart failure in senile patients

LIU Xu; XUE Jing; WANG Nan; LIU Yang

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Medical Journal of the Chinese People Armed Police Forces ›› 2018, Vol. 29 ›› Issue (4) : 336-340.

ORIGINAL ARTICLES

Clinical Effect of levosimendan in the treatment of refractory heart failure in senile patients

LIU Xu, XUE Jing, WANG Nan, LIU Yang

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Abstract

Objective To observe the clinical effect of levosimendan for treatment of refractory heart failure and mild renal dysfunction.Methods There were 36 heart failure patients on whom conventional heart failure therapies had poor effects. Each of these patients was given the continuous intravenous drip of levosimendan (0.05~0.2 μg/kg/min, according to the directions ) to observe the effects and side effects.Results The 36 patients used levosimendan for a total of 46 times, but some of these patients took this medicine on and off. After 72 hours of treatment, levels of NT-proBNP were significantly different(11785.22±10903.34 vs 5989.83±6044.02, P<0.05 ). LVEF and SV improved significantly in levosimendan group after treatment(35.11±4.21 vs 50.09±9.37; 37.22±17.26 vs 69.90±34.62, P<0.05). After treatment, the level of Cr showed no significant difference(716.02±342.75 vs 137.43±79.07, P>0.05), but the volume of urine was increased significantly(1383.57±431.14 vs 1906.72±522.70, P<0.05).ConclusionsLevosimendan can further improve heart function in patients with refractory heart failure.

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refractory heart failure / levosimendan / mild renal dysfunction

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LIU Xu, XUE Jing, WANG Nan, LIU Yang. Clinical Effect of levosimendan in the treatment of refractory heart failure in senile patients[J]. Medical Journal of the Chinese People Armed Police Forces. 2018, 29(4): 336-340

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