The predictive value of plasma BNP for recent ventricular remodeling in patients with  acute ST-segment elevation myocardial infarction after primary  percutaneous coronary intervention

DENG Lili; TIAN Zhiyu; ZHAO Wenping; WANG Yanfei; and GAO Shuxian

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Medical Journal of the Chinese People Armed Police Forces ›› 2019, Vol. 30 ›› Issue (10) : 853-856.

The predictive value of plasma BNP for recent ventricular remodeling in patients with acute ST-segment elevation myocardial infarction after primary percutaneous coronary intervention

DENG Lili¹, TIAN Zhiyu¹, ZHAO Wenping², WANG Yanfei², and GAO Shuxian²

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Abstract

Objective To investigate the predictive value of brain natriuretic peptide (BNP) levels for ventricular remodeling six months after primary percutaneous coronary intervention (p-PCI) in patients with acute myocardial infarction(AMI).Methods One hundred patients with acute ST segment elevation myocardial infarction (STEMI) were selected as the subjects, who had been treated with primary percutaneous coronary intervention (p-PCI) within 12 h of onset. The BNP levels were measured 24 hours after chest pain onset. The left ventricular end diastolic volume(LVEDV) was measured via echocardiography at the 7th day and 6th month after PCI. According to the results of echocardiography, the rate of increase of the left ventricular end diastolic volume was calculated:△LVEDV%=(the 6th month LVEDV-the 7th day LVEDV)/the 7th day LVEDV ×100%. Based on this rate of increase, all the patients were divided into the ventricular remodeling group(△LVEDV>20%,n=28)and non-remodeling group(△LVEDV<20%,n=72). The receiver operating characteristic (ROC) curve was drawn to investigate the predictive value of BNP levels 24 hour after onset for ventricular remodeling within 6 months.Results The area under the ROC curve of BNP levels 24 hours after onset was 0.844 when used to predict ventricular remodeling within 6 months,P<0.05. The cut-off value was 357.0 pg/ml, sensitivity of ventricular remodeling prediction was 75.0%, and specificity was 81.9%.Conclusions The significant increase of BNP levels in plasma 24 hours after the onset of acute myocardial infarction is an important risk factor for recent left ventricular remodeling in patients, which can help predict the occurrence of recent left ventricular remodeling.

Key words

acute ST-segment elevation myocardial infarction / brain natriuretic peptide / primary-PCI / ventricular remodeling

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DENG Lili, TIAN Zhiyu, ZHAO Wenping, WANG Yanfei, and GAO Shuxian. The predictive value of plasma BNP for recent ventricular remodeling in patients with acute ST-segment elevation myocardial infarction after primary percutaneous coronary intervention[J]. Medical Journal of the Chinese People Armed Police Forces. 2019, 30(10): 853-856

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