Meta-analysis of efficacy of two different approaches to femoral head decompression

YANG Kairui; DONG Hui; YANG Yang; WANG Kai; XING Jian; and XIA Qun

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Medical Journal of the Chinese People Armed Police Forces ›› 2019, Vol. 30 ›› Issue (10) : 861-865.

Original Articles

Meta-analysis of efficacy of two different approaches to femoral head decompression

YANG Kairui^{1, 2}, DONG Hui^{1, 3}, YANG Yang^{1, 4}, WANG Kai^{1, 5}, XING Jian^{1, 6}, and XIA Qun^{1, 7}

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Abstract

Objective To evaluate the efficacy of treating osteonecrosis of the femoral head(ONFH) with femoral head decompression combined with platelet-rich plasma and with femoral decompression alone.Methods Randomized clinical controlled trials (RCTs) which compared the therapeutic effects between femoral head decompression and platelet-rich plasma combined with surgery in both native and foreign language databases from inception to March 15, 2019 were retrieved from such databases as PubMed, Cochrane Library, CNKI and VIP. Related information was obtained and the quality of the study was evaluated.RevMan software was used for meta-analysis.Results Six studies involving 266 patients (307 hips) were included in this paper.There were 156 hips in the PRP group and 151 hips in the control group. The result of meta-analysis showed that compared with simple femoral head decompression, platelet-rich plasma combined with femoral head decompression could improve hip function Harris score MD=8.65[95%CI (7.12,10.18)]. The excellent rate of Harris score was increased OR=5.09[95%CI (2.40,10.80)]while the postoperative VAS score was reduced MD=-0.47[95%CI (-0.69,-0.25)], so was the disease progression rate OR=0.19[95%CI (0.06,0.57)]. There was statistically significant difference between the two groups.Conclusions Compared with simple femoral head decompression, platelet-rich plasma combined with femoral head decompression for femoral head osteonecrosis can achieve better clinical results.

Key words

platelet-rich plasma / osteonecrosis of the femoral head / femoral decompression / Meta-analysis

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YANG Kairui, DONG Hui, YANG Yang, WANG Kai, XING Jian, and XIA Qun. Meta-analysis of efficacy of two different approaches to femoral head decompression[J]. Medical Journal of the Chinese People Armed Police Forces. 2019, 30(10): 861-865

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