Expression of CCDC69 in breast cancer and its clinical significance

LIU Xiansheng; WANG Zhenguo; GAO Wenjie; YU Xiaoshuang; and REN Guibing

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Medical Journal of the Chinese People Armed Police Forces ›› 2019, Vol. 30 ›› Issue (10) : 890-893.

Original Articles

Expression of CCDC69 in breast cancer and its clinical significance

LIU Xiansheng¹, WANG Zhenguo², GAO Wenjie¹, YU Xiaoshuang¹, and REN Guibing³

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Abstract

Objective To investigate the expression of CCDC69 in breast cancer and its association with clinical features and prognosis of breast cancer patients, and to predict the role of CCDC69 in the development of breast cancer.Methods Breast cancer datasets were downloaded from the cancer genome atlas (TCGA) to obtain the CCDC69 gene expression profiles and clinical information. The expression levels of CCDC69 in breast cancer tissues and normal breast tissues were compared, and the correlations of CCDC69 expression levels with clinicopathological parameters and their impact on prognosis were analyzed. Gene enrichment analysis (GSEA) was used to predict the possible pathways regulated by CCDC69 in breast cancer.Results CCDC69 in breast cancer tissues was under-expressed compared with normal breast tissues (P<0.001),and low expression of CCDC69 was an independent risk factor affecting the prognosis of patients with breast cancer. CCDC69 expressions were associated with age (P=0.020) and tumor size (P=0.027). The overall survival of patients with low expressions of CCDC69 was shorter than that of patients with high expressions of CCDC69 (P=0.004). CCDC69 was negatively correlated with MYC signaling pathway, E2F signaling pathway, unfolded protein response and glycolysis gene sets.Conclusions CCDC69 may play a role as a tumor suppressor gene involved in the occurrence and development of breast cancer, and it can be potentially used as a therapeutic target and prognostic indicator.

Key words

breast cancer / CCDC69 / cancer genome atlas database / gene set enrichment / prognosis

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LIU Xiansheng, WANG Zhenguo, GAO Wenjie, YU Xiaoshuang, and REN Guibing. Expression of CCDC69 in breast cancer and its clinical significance[J]. Medical Journal of the Chinese People Armed Police Forces. 2019, 30(10): 890-893

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