Correlations between fibroblast growth factor-23 and femoral artery intima- media thickness in peritoneal dialysis patients

ZHANG Zhimin; GAO Feng; SHI Changqian; HE Xiao

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Medical Journal of the Chinese People Armed Police Forces ›› 2019, Vol. 30 ›› Issue (11) : 948-951.

Correlations between fibroblast growth factor-23 and femoral artery intima- media thickness in peritoneal dialysis patients

ZHANG Zhimin¹, GAO Feng², SHI Changqian², HE Xiao²

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Abstract

Objective To observe the correlations between fibroblast growth factor-23(FGF-23) and femoral artery intima- media thickness(IMT) in peritoneal dialysis patients.Methods Patients on continuous ambulatory peritoneal dialysis(CAPD) were divided into different groups according the femoral artery IMT. The relationships between FGF-23 and femoral artery IMT in different CAPD groups were analyzed.Results The incidence of increased femoral artery IMT in CAPD patients was 45.12%. Age, and levels of serum phosphorous、HbA₁c、intact parathyroid hormone( iPTH) and FGF-23 of the increased IMT group were significantly above those of the normal IMT group (P<0.05). According to multiple logistic regression analysis ,the levels of serum phosphorous、iPTH and a high FGF-23 concentration were significant independent risk factors for increased IMT in CAPD patients(P<0.05).Conclusions These results suggest that a high level of FGF-23 is an important indicator of calcium-phosphorus metabolism and vascular calcification in CKD patients, and maybe an important early warning signal of vascular calcification in CAPD patients.

Key words

peritoneal dialysis / fibroblast growth factor- 23 / femoral artery / intima- media thickness

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ZHANG Zhimin, GAO Feng, SHI Changqian, HE Xiao. Correlations between fibroblast growth factor-23 and femoral artery intima- media thickness in peritoneal dialysis patients[J]. Medical Journal of the Chinese People Armed Police Forces. 2019, 30(11): 948-951

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