Correlations between halo nevi and vitiligo and the effect of removing central nevus of a halo nevus on clinical outcomes

PDF(805 KB)

Medical Journal of the Chinese People Armed Police Forces ›› 2019, Vol. 30 ›› Issue (2) : 128-131.

LIU Jiyuan^1,2 and LU Tao¹

Author information +

History +

Abstract

Objective To study the correlations between halo nevi and vitiligo and to explore the curative effect of eliminating the central nevus of a halo nevus.Methods The clinical data on patients with halo nevi treated in the Department of Dermatology of our hospital between July 2010 and October 2017 was collected and analyzed statistically.Results The average age of 144 cases of halo nevi was (20.69±12.73)years, among whom there were 118 cases of single skin lesions (81.94%) and 26 cases (18.06%) of multiple skin lesions. The halo nevi occurred in the trunk (48.62%) and face and neck. (41.44%). Among the 125 patients with vitiligo, 108 (86.40%) were non-segmental and 17 (13.60%) were segmental, and the duration of the disease was longer when compared with patients with simple halo nevi (P=0.014). The clinical outcomes of 106 patients with vitiligo were followed up. The curative effect of eliminating the central nevus of halo nevi was better than that of the non operative treatment group (P=0.001), but there was no statistically significant difference between the two methods of CO₂ laser or surgical of central nevus of halo nevus(P=0.694). The overall effective rate was 91.67% in 17 patients with halo nevi who had the central nevus eliminated, which was significantly better than that of the non operative treatment group.Conclusions Halo nevus with a single lesion is frequently seen in adolescents, which occurs more frequently in the trunk and face and neck. Most of the halo nevi associated with vitiligo are non-segmental. The elimination of the central nevus can accelerate the regression of halo nevi and vitiligo.

Key words

halo nevus / vitiligo / clinical features / clinical relevancy / clinical curative effect

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

LIU Jiyuan and LU Tao. Correlations between halo nevi and vitiligo and the effect of removing central nevus of a halo nevus on clinical outcomes[J]. Medical Journal of the Chinese People Armed Police Forces. 2019, 30(2): 128-131

References

[1] Aouthmany M, Weinstein M, Zirwas M J, et al. The natural history of halo nevi: a retrospective case series[J]. J Am Acad Dermatol, 2012, 67(4):582-586.
[2] Itin P H, Lautenschlager S. Acquired leukoderma in congenital pigmented nevus associated with vitiligo-like depigmentation[J]. Pediatr Dermatol, 2002, 19(1):73-75.
[3] 中国中西医结合学会皮肤性病专业委员会色素病学组. 白癜风诊疗共识(2018版) [J]. 中华皮肤科杂志, 2018, 51(4): 247-250.
[4] 胡文婷, 许爱娥. 晕痣的研究进展 [J]. 中国皮肤性病学杂志, 2017,31(7): 800-802.
[5] Kolm I, Di Stefani A, Hofmann-wellenhof R, et al. Dermoscopy patterns of halo nevi[J]. Arch Dermatol, 2006, 142(12):1627-1632.
[6] Patrizi A, Bentivogli M, Raone B, et al. Association of halo nevus/i and vitiligo in childhood: a retrospective observational study[J]. J Eur Acad Dermatol Venereol, 2013, 27(2):e148-e152.
[7] 张倩, 李舒丽, 张伟刚,等. 277例晕痣的临床回顾性分析[J]. 临床皮肤科杂志, 2015,44(6):340- 343.
[8] Van Geel N, Vandenhaute S, Speeckaert R, et al. Prognostic value and clinical significance of halo naevi regarding vitiligo[J]. Br J Dermatol, 2011, 164(4):743-749.
[9] Van den Boorn J G, Konijnenberg D, Dellemijn T A, et al. Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients[J]. J Invest Dermato, 2009, 129(9):2220-2232.
[10] Schroder K, Hertzog P J, Ravasi T, et al. Interferon-γ: an overview of signals, mechanisms and functions[J]. J Leukoc Biol, 2004, 75(2):163-189.
[11] Yang Y, Li S, Zhu G, et al. A similar local immune and oxidative stress phenotype in vitiligo and halo nevus[J]. J Dermatol Sci, 2017,87(1):50-59.
[12] Hofmann U B, Brcker E B, Hamm H. Simultaneous onset of segmental vitiligo and a halo surrounding a congenital melanocytic naevus[J]. Acta Derm Venereol, 2009, 89(4):402-406.
[13] Zeff R A, Freitag A, Grin C M, et al. The immune response in halo nevi[J]. J Am Acad Dermatol, 1997, 37(4):620-624.
[14] Kim H S,Goh B K. Vitiligo Occurring after halo formation around congenital melanocytic nevi[J]. Pediatr Dermatol, 2009, 26(6):755-756.
[15] Stierman S C, Tierney E P, Shwayder T A. Halo congenital nevocellular nevi associated with extralesional vitiligo: a case series with review of the literature[J]. Pediatr Dermatol, 2009, 26(4):414-424.
[16] Suh J C, Yeum J S, Shin D J, et al. Clinical Study of Halo Nevi[J]. Korean J Dermatol,2001,39(6):648-653.
[17] 汪京峡, 徐平, 夏莉,等. 白癜风患者血清中抗黑素细胞IgG抗体的检测及意义[J]. 皮肤病与性病, 2004, 26(3):1-2.
[18] Wang K, Wang Z, Huang W. Resolution of vitiligo following excision of halo congenital melanocytic nevus: a rare case report[J]. Dermatol Ther, 2016, 29(3):145-147.
[19] Workman M, Sawan K, EI Amm C. Resolution and recurrence of vitiligo following excision of congenital melanocytic nevus[J]. Pediatr Dermatol, 2013,30(6):166-168.
[20] Park H S, Jin S A, Choi Y D, et al. Foxp3+ regulatory T cells are increased in the early stages of halo nevi: clinicopathological features of 30 halo nevi[J]. Dermatology, 2012,225 (2):172-178.
[21] Lee N R, Chung H C, Hong H, et al. Spontaneous involution of congenital melanocytic nevus with halo phenomenon[J]. Am J Dermatopathol, 2015, 37(12): e137-e139.
[22] Arpaia N, Cassano N, Filotico R, et al. Unusual clinical presentation of regression in a congenital melanocytic nevus[J]. Dermatol Surg, 2005, 31(4):471-473.