MiR-494 inhibits tumor progression by targeting LETMD1 in cervical cancer

LI Xin; DONG Lixin; YANG Sen; CAO Liyan; MAO Yu; FU Zhanzhao; DONG Siqi

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Medical Journal of the Chinese People Armed Police Forces ›› 2019, Vol. 30 ›› Issue (3) : 205-208.

MiR-494 inhibits tumor progression by targeting LETMD1 in cervical cancer

LI Xin^1,2,DONG Lixin²,YANG Sen², CAO Liyan²,MAO Yu²,FU Zhanzhao²,DONG Siqi³

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Abstract

Objective To explore the role of LETMD1-targeting miR-494 in the progression of cervical cancer.Methods miRNA-494 mRNA and LETMD1 protein expressions in clinical samples were determined to confirm the effects on cell proliferation, invasion and migration.Results The expression of miR-494 in tissue samples of cervical cancer was significantly decreased, and its expression level was negatively correlated with the FIGO stage (P<0.05). LETMD1 was identified as a target gene of miR-494 in cervical cancer cells by dual-luciferase assay. Functional experiments demonstrated that miR-494 could inhibit the cell proliferation via the negative regulation of LETMD1 expression.Conclusions Our findings provide important evidence for the role of miR-494 as a tumor suppressor in cervical cancer via the inhibition of LETMD1 expression.

Key words

LETMD1 / miR-494 / cervical cancer / FIGO stage / proliferation

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LI Xin,DONG Lixin,YANG Sen, CAO Liyan,MAO Yu,FU Zhanzhao,DONG Siqi. MiR-494 inhibits tumor progression by targeting LETMD1 in cervical cancer[J]. Medical Journal of the Chinese People Armed Police Forces. 2019, 30(3): 205-208

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