Relationships between CRABP-Ⅰ expression in serum of adult patients with moyamoya disease and postoperative hemodynamic changes

HE Xin; WANG Jianzhen; LI Xin; ZHAO Shuiqiang; WANG Zhen; QIN Zhizhen

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Medical Journal of the Chinese People Armed Police Forces ›› 2019, Vol. 30 ›› Issue (5) : 388-390.

Relationships between CRABP-Ⅰ expression in serum of adult patients with moyamoya disease and postoperative hemodynamic changes

HE Xin, WANG Jianzhen, LI Xin, ZHAO Shuiqiang, WANG Zhen, QIN Zhizhen

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Abstract

Objective To investigate the expressions of serum CRABP-Ⅰ in adults with moyamoya disease and the postoperative changes of hemodynamics.Methods Serum levels of CRABP-Ⅰ in 52 patients with moyamoya disease were measured by ELISA before operation and 6 months after operation. Serum samples from 20 healthy volunteers were taken as control. The correlations between serum levels of CRABP-Ⅰ and cerebral blood perfusion before and after operation were analyzed.Results Compared with the control group, the serum levels of CRABP-Ⅰ in moyamoya disease patients were increased significantly both before and after operation [(19.70±5.10) mg/L vs (35.38±6.05) mg/L, (28.38±4.46) mg/L; P<0.01)]. These levels decreased significantly after operation (P<0.01). The serum CRABP-Ⅰ concentrations in patients at Suzuki stage 1-2 and 3-4 were significantly lower 6 months after operation[(28.17±4.88) mg/L vs (37.75±5.66) mg/L, P<0.01)]. The serum CRABP-Ⅰ concentrations in patients at Suzuki stage 3-4 were significantly higher than those in patients at Suzuki stage 1-2 (P<0.01). The postoperative rTTP of patients was significantly lower after operation (P=0.001). The preoperative and postoperative serum CRABP-Ⅰ concentrations were positively correlated with rTTP (P<0.01).Conclusion CRABP-Ⅰ may be involved in the occurrence and development of moyamoya disease and can be used as a serological marker and indicator of hemodynamic improvement.

Key words

moyamoya disease / CRABP-Ⅰ / magnetic resonance perfusion imaging

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HE Xin, WANG Jianzhen, LI Xin, ZHAO Shuiqiang, WANG Zhen, QIN Zhizhen. Relationships between CRABP-Ⅰ expression in serum of adult patients with moyamoya disease and postoperative hemodynamic changes[J]. Medical Journal of the Chinese People Armed Police Forces. 2019, 30(5): 388-390

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