Prediction of atrial fibrillation occurrence in pneumonia geriatrics with procalcitonin,C-reactive protein and NT-pro BNP

GAN Zhuokun; TIAN Haitao

PDF(723 KB)

Medical Journal of the Chinese People Armed Police Forces ›› 2019, Vol. 30 ›› Issue (6) : 488-492.

Prediction of atrial fibrillation occurrence in pneumonia geriatrics with procalcitonin,C-reactive protein and NT-pro BNP

GAN Zhuokun TIAN Haitao

Author information +

History +

Abstract

Objective To compare the ability of procalcitonin, C-reactive protein(CRP) and N-terminal pro-B-type natriuretic peptide(NT-pro BNP) to predict the occurrence of atrial fibrillation in geriatric community acquired pneumonia(CAP) patients.Methods Geriatric patients with CAP or without infections were enrolled in this study and divided into two groups: CAP group and control group(non-infection group) , while patients with mitral stenosis and other diseases were excluded. These patients were examined with electrocardiograms and cardiac ultrasound and had their blood detected quickly. The incidence and types of atrial fibrillation were observed. The ability of the initial values and peak values three months after hospitalization of PCT、CRP and NT-proBNP to predict atrial fibrillation was calculated.Results A total of 156 male patients were enrolled, including 120 patients with CAP and 36 patients as control. Morbidity was higher in the CAP group. PCT had the highest positive predictive value for the occurrence of atrial fibrillation, while the initial diagnostic value of PCT and peak value of CRP after three months displayed the highest negative predictive value.Conclusions PCT may be a promising option to predict the chance of atrial fibrillation among geriatric patients of CAP in the early stage. Persistent negative values of CRP indicate less chance of atrial fibrillation.

Key words

community acquired pneumonia / geriatrics / atrial fibrillation / biomarkers / prediction

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

GAN Zhuokun TIAN Haitao. Prediction of atrial fibrillation occurrence in pneumonia geriatrics with procalcitonin,C-reactive protein and NT-pro BNP[J]. Medical Journal of the Chinese People Armed Police Forces. 2019, 30(6): 488-492

References

[1] Briffa T, Hung J, Knuiman M. Trends in incidence and prevalence of hospitalization for atrial fibrillation and associated mortality in Western Australia 1995-2010[J]. Int J Cardiol, 2016, 208: 19-25.
[2] Shaver C M, Chen W, Janz D R, et al. Atrial fibrillation is an independent predictor of mortality in critically ill patients[J]. Crit Care Med, 2015, 43(10):2104-2111.
[3] Kuipers S, Klein Klouwenberg P M, Cremer O L. Incidence, risk factors and outcomes of new-onset atrial fibrillation in patients with sepsis: a systematic review [J]. Crit Care, 2014, 18(6): 688.
[4] Christ-Crain M, Breidthardt T, Stolz D, et al. Use of B-type natriuretic peptide in the risk strati?cation of community-acquired pneumonia [J]. J Intern Med, 2008, 264(2):166-176.
[5] Rudiger A, Fischler M, Harpes P, et al. In critically ill patients, B-type natriuretic peptide (BNP) and N-terminal pro-BNP levels correlate with C-reactive protein values and leukocyte counts [J]. Int J Cardio, 2008, 126(1): 28-31.
[6] Aviles R J, Martin D O, Apperson-Hansen C, et al. Inflammation as a risk factor for atrial fibrillation[J]. Circulation, 2003, 108(24): 3006-3010.
[7] Schnabel R B, Larson M G, Yamamoto J F, et al. Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community[J]. Circulation, 2010, 121(2): 200-207.
[8] Kwon C H, Kang J G, Lee H J, et al. C-reactive protein and risk of atrial fibrillation in East Asians[J]. Europace, 2017, 19(10):1643-1649.
[9] Hatzinikolaou-Kotsakou E, Tziakas D, Hotidis A, et al. Relation of c-reactive protein to the first onset and the recurrence rate in lone atrial fibrillation[J]. Am J Cardiology, 2006, 97(5):659-661.
[10] Scridon A, Morel E, Nonin-Babary E, et al. Increased intracardiac vascular endothelial growth factor levels in patients with paroxysmal, but not persistent atrial fibrillation [J]. Europace, 2012, 14(7): 948-953.
[11] Zhang P, Shao L, Ma J. Toll-Like receptors 2 and 4 predict new-onset atrial fibrillation in acute myocardial infarction patients[J]. Int Heart J, 2018, 59(1): 64-70.
[12] Klein Klouwenberg P M, Frencken J F, Kuipers S, et al. Incidence, predictors, and outcomes of new-onset atrial fibrillation in critically ill patients with sepsis. A cohort study[J]. Am J Respir Crit Care Med, 2017, 195(2): 205-211.
[13] Wu C C, Lan H M, Han S T, et al. Comparison of diagnostic accuracy in sepsis between presepsin, procalcitonin, and C-reactive protein: a systematic review and meta-analysis[J]. Ann Intensive Care,2017,7(1): 91.
[14] Muller F, Christ-Crain M, Bregenzer T, et al. Procalcitonin levels predict bacteremia in patients with community-aquired pneumonia: a prospective cohort trial[J]. Chest, 2010, 138(1): 121-129.
[15] Kristensen S L, Jhund P S, Mogensen U M, et al. Prognostic value of N-terminal pro-B-type natriuretic peptide levels in heart failure patients with and without atrial fibrillation[J]. Circ Heart Fail, 2017, 10(10): Kristensen S L , Jhund P S , Mogensen U M , et al. Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide Levels in Heart Failure Patients With and Without Atrial Fibrillation[J]. Circulation: Heart Failure, 2017, 10(10): e004409.
[16] Jeong K Y, Kim K, Kim T Y, et al. Prognostic value of N-terminal pro-brain natriuretic peptide in hospitalised patients with community-acquired pneumonia[J]. Emerg Med J, 2011, 28(2): 122-127.
[17] Hayase N, Yamamoto M, Asada T, et al. Association of heart rate with N-terminal pro-B-type natriuretic peptide in septic patients: a prospective observational cohort study[J]. Shock, 2016, 46(6):642-648.