Objective To investigate the safety and efficacy of “one-stitch anastomosis through the skin combined with bicanalicular intubation” in the treatment of canalicular laceration of infants.Methods A retrospective analysis was performed of 9 eyes (9 cases) of infants (≤3 year old)with canalicular laceration treated with “one-stitch anastomosis through the skin combined with bicanalicular intubation”. According to the location of canalicular laceration, a corresponding surgical plan was developed by using the method of one-stitch anastomosis through the skin combined with bicanalicular intubation. The lacrimal stent was removed after 3 months of intubation.Results The average age of these nine infants was (1.64±0.30) years, ranging from 9 months to 3 years. There were 5 males (55.56%) and 4 females (44.44%). Four cases underwent inferior canalicular laceration anastomosis and bicanalicular intubation, two cases underwent superior lacrimal canalicular laceration anastomosis and bicanalicular intubation, and three cases underwent inferior and superior canalicular laceration anastomosis and bicanalicular intubation .Eight cases were cured and one case was improved. All the patients had no orbital or medial deformity. The follow-up period was 6-36 months.Conclusions “One-stitch anastomosis through the skin combined with bicanalicular intubation” is safe and effective in the treatment of canalicular laceration of infants.