Objective To observe the efficacy and safety of recombinant human brain natriuretic peptide (rhBNP) when used in elderly patients.Methods A total of 319 elder patients with heart failure were chosen from our hospital between January 2012 and June 2017.They were randomly divided into the control group (n=138) and rhBNP treatment group (n=181).Patients in both groups were observed and compared in terms of type B natriuretic peptide (NT-proBNP), left ventricular ejection fraction (LVEF), ventricular shortening index (FS), the 6-minute walk test (6 MWT), changes of liver function, renal function and blood pressure, and the difference in the rate of re-hospitalization.Results After 5 days, the level of NT-proBNP in the rhBNP treatment group was significantly lower than that in the control group (P<0.05), but LVEF, FS and 6MWT increased (P<0.05). Three months after treatment, the level of NT-proBNP in the rhBNP treatment group was significantly lower than that in the control group (P<0.05), but LVEF, FS and 6MWT improved significantly (P<0.05). After 3 months of treatment, the rate of re-hospitalization in the rhBNP treatment group was significantly lower than that in the control group (P<0.05).Conclusions Recombinant human brain natriuretic peptide (rhBNP) is safe and effective in the treatment of acute exacerbation of chronic heart failure in elderly patients, which can reduce the re-hospitalization rate of heart failure that occurs within 3 months.
Key words
recombinant human brain natriuretic peptide /
elderly people /
heart failure
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