Distribution and drug resistance of fungal blood stream infections in a military hospital from 2013 to 2018

LI Jixia; XUE Lian; WU Jing; CUI Hairong; MIN Yan; SUN Xiao

PDF(655 KB)

Medical Journal of the Chinese People Armed Police Forces ›› 2019, Vol. 30 ›› Issue (9) : 772-775.

ORIGINAL ARTICLES

Distribution and drug resistance of fungal blood stream infections in a military hospital from 2013 to 2018

LI Jixia, XUE Lian, WU Jing, CUI Hairong, MIN Yan, SUN Xiao

Author information +

History +

Abstract

Objective To investigate the current fungal blood stream infections and to provide reference for the prevention and treatment of fungemia.Methods Retrospective analysis was used to test the results of fungal blood stream infections in a military hospital between 2013 and 2018. The species, distribution and drug resistance were analyzed.Results 97 strains of fungal blood stream infections were isolated, mainly Candida albicans(30.93%), but the proportion decreased(from 41.76% in 2013 to 27.78% in 2018). Fungal blood stream infections occurred most often in departments of hematology(24.74%) and intensive care medicine (22.68%). The sensitivities to four antimicrobial agents were as follows: 5-fluorocytosine (97.80%), voriconazole (97.80%), fluconazole (93.30%), and itraconazole (71.10%).Conclusions Candida albicans is the main fungus associated with blood stream infections, but infections with non-Candida albicans are on the rise. Improving immunity and reducing invasive examination and treatment are important to reduce fungal blood flow in fection.Triazoles are still the mainstream antifungal drugs, and resistance needs to be tested in the course of treatment.

Key words

blood stream infection / fungus / fungemia / analysis

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

LI Jixia, XUE Lian, WU Jing, CUI Hairong, MIN Yan, SUN Xiao. Distribution and drug resistance of fungal blood stream infections in a military hospital from 2013 to 2018[J]. Medical Journal of the Chinese People Armed Police Forces. 2019, 30(9): 772-775

References

[1] 黄小燕,赵喜荣,苏建忠,等.院内感染254例现状分析[J].武警医学,2018,29(1):71-72.
[2] Kullberg B J,Arendrup M C.Invasive candidiasis[J].N Engl J Med,2015,373(15):1445-1456.
[3] 张立娜,贺政新,安黎云,等.真菌血症患者血小板计数动态变化回顾分析[J].检验医学与临床,2015,12(3):312-316.
[4] 凌勇,侯铁英,陈柳勤,等.250例真菌性血流感染的临床特点分析[J].中华医院感染学杂志,2016,26(21):4876-4881.
[5] 陈玉,鲁俊锋,魏兵,等.82例念珠菌血症患者的临床分析[J].中华实验和临床感染病杂志(电子版), 2017,11(4):373-376.
[6] Cornely O A, Gachot B, Akan H, et al. Epidemiology and outcome of fungemia in a cancer cohort of the Infectious Diseases Group (IDG) of the European Organization for Research and Treatment of Cancer (EORTC 65031) [J].Clin Infect Dis,2015,61(3):324-331.
[7] Peron I H,Reichert L F,Busso L A F,et al.Resistance surveillance in Candida albicans:a five-year antifungal susceptibility evaluation in a Bbrazilian University Hospital[J]. PLoS One,2016,11(7):e0158126.
[8] Eliakim R N,Babaoff R,Yahav D,et al.Epidemiology,microbiology,clinical characteristics,and outcomes of candidemia in internal medicine wards-a retrospective study[J].Int J Infect Dis,2016,52:49-54.
[9] Montagna M T,Caggiano G,Lovero G,et al.Epidemiology of invasive fungal infections in the intensive care unit:results of a multicenter Italian survey(AURORA Project)[J].Infection,2013,41(3):645-653.
[10] Guimaraes T,Nucci M, Mendonca J S,et al.Epidemiology and predictors of a poor outcome in elderly patients with candidemia[J].Int J Infect Dis,2012,16(6):e442-e447.
[11] 公衍文,李继霞,胡成进.侵袭性真菌感染可疑病原菌种分布及其耐药现状[J].国际检验医学杂志,2013,34(22):3003-3004.
[12] 宁永忠.2016 美国感染性疾病学会念珠菌病处置的临床实践指南解读[J]. 中华临床实验室管理电子杂志, 2016, 4(3):148-152.
[13] 李春年,吴小军.19284份血培养的真菌分布和临床特点分析[J].临床肺科杂志,2017,22(12):2175-2178.
[14] Calandra T,Roberts J A,Antonelli M,et al.Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy[J].Crit Care,2016,20(1):125.
[15] 符加红,赵阳,栾婷,等.ICU血行感染早期降钙素原变化幅度的比较[J].中国呼吸与危重监护杂志,2014,13(2):158-161.
[16] 黄道政,张佳佳,王首红,等.降钙素原在早期诊断高龄危重患者念珠菌败血症中的作用[J].广东医学,2013,34(7):1061-1063.