Objective To investigate the clinical effect of letrozole in the treatment of patients with idiopathic oligozoospermia.Methods A total of 150 patients with idiopathic oligozoospermia admitted to our hospital between April 2015 and January 2018 were divided into group A (n=50, letrozole tablets), group B (n=50, tamoxifen citrate) and group C (n=50, placebo) using random number table method. After 3 months of treatment, the sex hormone levels (E2, T, FSH, LSH, PRL, T/E2, INHB), general parameters of semen, testicular volume and BMI before and after treatment were compared.Results After treatment, the total effective rate of group A was significantly higher than that of group B and group C (96.0% vs 84.0% vs 28.0%, P<0.05). After treatment, the serum levels of FSH, LH, T, INH-B and T/E2 ratios in group A were significantly higher than those in group B and group C, but the serum E2 level was lower (P<0.05). After treatment, the sperm concentration, sperm count and normal sperm morphology in group A were significantly increased (P<0.05). The average effective sperm count increase in group A was significantly higher than that of group B and group C (P<0.05).Conclusions The use of letrozole in the treatment of idiopathic oligozoospermia can significantly improve the T and FSH levels, T/E2 ratios as well as semen quality, which has a good clinical effect.
Key words
letrozole /
idiopathic oligozoospermia /
clinical efficacy /
sex hormone
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 张明亮, 郑小挺, 张端军,等. 中西医联合治疗特发性少弱精子症的疗效观察[J]. 现代诊断与治疗, 2018,29,257(5):30-31.
[2] 关立军, 赵慧霞, 郑 波,等. 他莫昔芬联合小剂量睾酮治疗特发性少弱精子症的随机对照研究[J]. 中国计划生育和妇产科, 2018, 10(1):67-69.
[3] Huang Y P, Liu W, Liu Y D, et al. Right testicular volume is a dominant predictor of testicular function determined by sperm parameters and total testosterone[J]. Andrologia,2018, 50(4):e12955.
[4] 蒲江波, 李雪梅, 朱文杰,等. 绒促性素联合小剂量雄激素治疗少精子症及弱精子症效果观察[J]. 山东医药, 2016, 56(30):89-91.
[5] 谷翊群. 世界卫生组织人类精液检查与处理实验室手册[M]. 北京:人民卫生出版社, 2011:47-49.
[6] 王晓峰, 朱积川, 邓春华. 中国男科疾病诊断治疗指南[M]. 北京:人民卫生出版社, 2013:12-13.
[7] 薛丹丹, 刘 萍, 马骏龙,等. 从4340份精液检查结果分析探讨不育的主要因素[J]. 武警医学, 2016, 27(5):444-446.
[8] Wang J, Tang C, Wang Q, et al. NRF1 coordinates with DNA methylation to regulate spermatogenesis[J]. FASEB J, 2017, 31(11):4959.
[9] 张守波, 曹 凤, 赵元淑,等. 不动精子症助孕成功1例[J]. 武警医学, 2017, 28(10):1055-1056.
[10] Liu H J, Yan J, Li Y, et al. Low aromatase activity and estradiol/sex hormone binding globulin ratio are associated with total hip bone mineral density and the presence of osteoporosis: a study in Chinese postmenopausal women[J]. Horm Metab Res, 2018, 50(1):65-72.
[11] 曾 勇,宋明哲,赵 明,等.性激素负反馈作用在男性不育诊疗中的应用[J]. 生殖医学杂志, 2017, 26(8):743-748.
[12] De C B, Ball G F, Balthazart J, et al. Rapid changes in brain aromatase activity in the female quail brain following expression of sexual behavior.[J]. J Neuroendocrinol, 2017, 29(11):e12542.
[13] 刘兆祥, 茅江峰, 伍学焱,等. 芳香化酶抑制剂(来曲唑)可有效治疗男性部分性特发性低促性腺激素性性腺功能减退症[J]. 中华内分泌代谢杂志, 2016, 32(2):125-127.
[14] 杨 梅. 他莫昔芬与来曲唑在绝经后乳腺癌辅助内分泌治疗中临床对比研究[J]. 海南医学院学报, 2016, 22(9):910-912.
[15] Liu M J, Wang E H. Impact of varicocele on semen quality and inhibin B concentration in serum and seminal plasma[J]. Int J Androl, 2014, 20(20):44-47.
PDF(677 KB)
