Changes of serum IL-18, sICAM-1 and IGF-1 in patients with cerebral infarction treated with Cinepazide Maleate and Danshen Ligustrazine injection

GUO Xiaoying; SUN Changyou; GAO Li; MA Biao

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Medical Journal of the Chinese People Armed Police Forces ›› 2020, Vol. 31 ›› Issue (3) : 211-214.

Changes of serum IL-18, sICAM-1 and IGF-1 in patients with cerebral infarction treated with Cinepazide Maleate and Danshen Ligustrazine injection

GUO Xiaoying¹, SUN Changyou¹, GAO Li², MA Biao³

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Abstract

ObjectiveTo investigate the therapeutic effect of Cinepazide Maleate combined with Danshen Ligustrazine injection against cerebral infarction by observing changes in serum interleukin (IL)-18, soluble intercellular adhesion molecule (sICAM)-1, and insulin-like growth(IGF)-1 in patients.Methods One hundred and thirty-five cases of patients with cerebral infarction who were treated in our hospital between September 2015 and December 2018 were selected and divided into the control group(n=65) and the combination group(n=70) according to treatment methods. The control group was treated with Cinepazide Maleate, while the combination group was additionally treated with Danshen Ligustrazine injection. Both groups were treated for 3 months, and the levels of serum IL-18, sICAM-1 and IGF-1 were detected and recorded.Results All the patients completed the treatment and no serious adverse reactions occurred during the treatment. The total effective rate of the combination group was 97.1%, which was significantly higher than that of the control group (86.2%) (P<0.05). The MoCA scores, cranial vertebral artery and basilar artery blood flow velocity in the two groups were significantly higher after treatment (P<0.05), especially in the combination group (P<0.05). The levels of serum IL-18, sICAM-1 and IGF-1 in the two groups were significantly lower after treatment (P<0.05), particularly in the combination group (P<0.05).Conclusions Cinepazide Maleate combined with Danshen Ligustrazine injection, when used in the treatment of cerebral infarction, can inhibit the expressions of serum IL-18, sICAM-1 and IGF-1, boost the cerebral blood flow and improve the cognitive function and overall therapeutic effect.

Key words

Cinepazide Maleate / Danshen Ligustrazine injection / cerebralinfarction / interleukin-18 / soluble intercellular adhesion molecule-1

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GUO Xiaoying, SUN Changyou, GAO Li, MA Biao. Changes of serum IL-18, sICAM-1 and IGF-1 in patients with cerebral infarction treated with Cinepazide Maleate and Danshen Ligustrazine injection[J]. Medical Journal of the Chinese People Armed Police Forces. 2020, 31(3): 211-214

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