[1] Zhang M, Zhao Q C, Liu Y P, et al. Prognostic analysis and comparison of colon cancer in Han and Hui patients[J]. World J Gastroenterol, 2014,20(17):5082-5086.
[2] Terzic J, Grivennikov S, Karin E, et al. Inflammation and colon cancer[J]. Gastroenterology, 2010,138(6):2101-2114.
[3] Binefa G, Rodriguez-Moranta F, Teule A, et al. Colorectal cancer: from prevention to personalized medicine[J]. World J Gastroenterol, 2014,20(22):6786-6808.
[4] Jing K, Wu T, Lim K. Omega-3 polyunsaturated fatty acids and cancer[J]. Anticancer Agents Med Chem, 2013,13(8):1162-1177.
[5] 裴利娟, 刘飞德. ω-3多不饱和脂肪酸与结直肠癌防治研究进展[J]. 中国急救复苏与灾害医学杂志, 2014,9(5):459-461.
[6] Han Y M, Jeong M, Park J M, et al. The omega-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of beta-catenin complex, inhibiting COX-2 through repressing NF-kappaB, and inducing 15-prostaglandin dehydrogenase[J]. Oncotarget, 2016,7(39):63583-63595.
[7] Simopoulos A P. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases[J]. Exp Biol Med, 2008,233(6):674-688.
[8] Zhang K, Hu Z, Qi H, et al. G-protein-coupled receptors mediate omega-3 PUFAs-inhibited colorectal cancer by activating the Hippo pathway[J]. Oncotarget, 2016,7(36):58315-58330.
[9] Yu F X, Meng Z, Plouffe S W, et al. Hippo Pathway Regulation of Gastrointestinal Tissues[J]. Annu Rev Physiol, 2015,77(1):201-227.
[10] 王 磊. ω-3多不饱和脂肪酸对结肠癌治疗作用机制的研究[D]. 扬州:扬州大学, 2013.
[11] Serini S, Cassano R, Corsetto P, et al. Omega-3 PUFA loaded in resveratrol-based solid lipid nanoparticles: physicochemical properties and antineoplastic activities in human colorectal cancer cells in vitro[J]. Int J Mol Sci, 2018,19(2):586.
[12] Khan S A, Heuvel J P V. Reviews: current topicsrole of nuclear receptors in the regulation of gene expression by dietary fatty acids (review)[J]. J Nutr Biochem, 2003,14(10):554-567.
[13] Luigi F, Antonio C, Stefania B, et al. Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers[J]. J Clin Endocrinol Metab, 2006,91(2):439-446.
[14] He J. Relationship of serum polyunsaturated fatty acids with cytokines in colorectal cancer[J]. World J Gastroenterol, 2016,22(8):2524.
[15] Winer S, Paltser G, Chan Y, et al. Obesity predisposes to Th17 bias[J]. Eur J Immunol, 2009,39(9):2629-2635.
[16] Moon H S, Chamberland J P, Diakopoulos K N, et al. Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues: in vitro and ex vivo studies in humans[J]. Diabetes Care, 2011,34(1):132-138.
[17] Massimo D, Beatrice S, Stefania G, et al. ω3-PUFAs exert anti-inflammatory activity in visceral adipocytes from colorectal cancer patients[J]. PLoS One, 2013,8(10):e77432.
[18] Fluckiger A, Dumont A, Derangere V, et al. Inhibition of colon cancer growth by docosahexaenoic acid involves autocrine production of TNFalpha[J]. Oncogene, 2016,35(35):4611-4622.
[19] Peters U, Bien S, Zubair N. Genetic architecture of colorectal cancer[J]. Gut, 2015,64(10):1623-1636.
[20] Wang W, Yang J, Nimiya Y, et al. ω-3 Polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice[J]. J Nutr Biochem, 2017,48:29-35.
[21] Chen Z, Zhang Y, Jia C, et al. mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression[J]. Oncogene, 2014,33(37):4548-4557.
[22] Liu M, Zhou L, Zhang B, et al. Elevation of n-3/n-6 PUFAs ratio suppresses mTORC1 and prevents colorectal carcinogenesis associated with APC mutation[J]. Oncotarget, 2016,7(47):76944-76954.
[23] Morin C, Rodríguez E, Blier P, et al. Potential application of eicosapentaenoic acid monoacylglyceride in the management of colorectal cancer[J]. Marine Drugs, 2017,15(9):283.
[24] Dimberg L Y, Anderson C K, Camidge R, et al. On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics[J]. Oncogene, 2013,32(11):1341-1350.
[25] Skender B, Hofmanová J, Slavík J, et al. DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism[J]. Biochim Biophys Acta, 2014,1841(9):1308-1317.
[26] Lu X, Yu H, Ma Q, et al. Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction[J]. Lipids Health Dis, 2010,9:106.
[27] Bjornsson H T, Fallin M D, Feinberg A P. An integrated epigenetic and genetic approach to common human disease[J]. Trends Genet, 2004,20(8):350-358.
[28] 黄琼林, 李兆锦, 李 健, 等. ω-3 PUFAs抑癌过程的基因组DNA甲基化及羟甲基化分析[C].中国化学会第十一届全国生物医药色谱及相关技术学术交流会, 井冈山, 2016.
[29] Huang Q, Wen J, Chen G, et al. Omega-3 Polyunsaturated Fatty Acids Inhibited Tumor Growth via Preventing the Decrease of Genomic DNA Methylation in Colorectal Cancer Rats[J]. Nutr Cancer, 2016,68(1):113-119.
[30] Sarabi M M, Naghibalhossaini F. The impact of polyunsaturated fatty acids on DNA methylation and expression of DNMTs in human colorectal cancer cells[J]. Biomed Pharmacother, 2018,101:94-99.
[31] Cho Y, Turner N D, Davidson L A, et al. Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation[J]. Exp Biol Med, 2014,239(3):302-310.
[32] 陆 怡, 濮丽英, 周利群, 等. 免疫营养在恶性肿瘤治疗中的研究现状及进展[J]. 现代肿瘤医学, 2017,25(22):3722-3726.
[33] 王迎春, 王金华. ω-3多不饱和脂肪酸对肿瘤细胞侵袭转移的影响及机制研究进展[J]. 肿瘤学杂志, 2016,22(3):236-241.
[34] Miccadei S, Masella R, Mileo A M, et al. Omega3 polyunsaturated fatty acids as immunomodulators in colorectal cancer: new potential role in adjuvant the rapies[J]. Front Immunol, 2016,7:486.
[35] Xie H, Chang Y N. Omega-3 polyunsaturated fatty acids in the prevention of postoperative complications in colorectal cancer: a meta-analysis[J]. Onco Targets Ther, 2016,9:7435-7443.
[36] Slagsvold J E, Pettersen C H H, St Rvold G L, et al. DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells.[J]. Nutr Cancer Int J, 2010,62(5):611-621.
[37] Wang J, Luo T, Li S, et al. The powerful applications of polyunsaturated fatty acids in improving the therapeutic efficacy of anticancer drugs[J]. Expert Opin Drug Deliv, 2012,9(1):1-7.