Correlations between expressions of TUBB3 gene mRNA and prognosis in 92 patients of non-small cell lung cancer

ZHAO Yunlong; LI Jingbo; ZHAO Yingnan; CHEN Ping; LIU Bo; LIU Yang

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Medical Journal of the Chinese People Armed Police Forces ›› 2020, Vol. 31 ›› Issue (5) : 397-400.

ORIGINAL ARTICLES

Correlations between expressions of TUBB3 gene mRNA and prognosis in 92 patients of non-small cell lung cancer

ZHAO Yunlong¹, LI Jingbo¹, ZHAO Yingnan¹, CHEN Ping¹, LIU Bo¹, LIU Yang²

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Abstract

Objective To evaluate the correlations between the expression of TUBB3 mRNA and the prognosis of NSCLC patients who can be treated surgically. Methods The expression of TUBB3 gene mRNA was detected with branch DNA liquid chips in 92 NSCLC patients who were followed up for 60 months. Results Low expressions of TUBB3 promised longer overall survival (48.7 vs 35.8 months, HR=1.56, 95% CL:1.45-2.56, P=0.017) in these patients. The median progression-free survival was longer in patients with low expressions of TUBB3 mRNA than in those with high expressions (35.7 months vs 23.5 months, P=0.001, HR=1.33,95% Cl:1.06-2.32). Conclusions TUBB3 mRNA expressions may be a factor that can help predict the prognosis of NSCLC patients.

Key words

NSCLC / TUBB3 / overall survival / progression-free survival / prognostic factor

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ZHAO Yunlong, LI Jingbo, ZHAO Yingnan, CHEN Ping, LIU Bo, LIU Yang. Correlations between expressions of TUBB3 gene mRNA and prognosis in 92 patients of non-small cell lung cancer[J]. Medical Journal of the Chinese People Armed Police Forces. 2020, 31(5): 397-400

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