Meta-analysis of safety and tolerability of prostacyclin analogues for pulmonary arterial hypertension

YIN Dawei; SHI Hanyu; WEI Luqing

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Medical Journal of the Chinese People Armed Police Forces ›› 2020, Vol. 31 ›› Issue (7) : 553-556.

ORIGINAL ARTICLES

Meta-analysis of safety and tolerability of prostacyclin analogues for pulmonary arterial hypertension

YIN Dawei^1,2, SHI Hanyu^1,2, WEI Luqing¹

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Abstract

Objective To evaluate the safety and tolerability of prostacyclin analogues (PA) in the treatment of pulmonary arterial hypertension (PAH).Methods Such databases as CNKI, WanFang Data, VIP, PubMed and Embase were searched for randomized controlled trials (RCTs)in which PAs were used in the treatment of PAH. Literature was screened, data was extracted and the quality of the study was assessed. RevMan5.3 and StataV12.0 software were used for meta-analysis.Results Sixteen RCT studies involving 3,726 patients were included in this research. The result of meta-analysis showed that the incidence of at least one adverse events (AEs)[RR=1.05, 95%CI(1.00, 1.10), P=0.04] and discontinuation [RR=1.81, 95%CI(1.08, 3.05), P=0.02] in the test group was higher than that in the control group, and the difference was statistically significant. The chance of specific AEs in the test group was also higher than in the control group. The incidence rates of at least one serious adverse event [RR=0.93, 95%CI(0.83, 1.04), P=0.20] was not significantly different between the two groups.Conclusions PAs are relatively safe, but there is still the risk of tolerability in PAH patients.

Key words

pulmonary arterial hypertension / prostacyclin analogues / systematic review / meta-analysis / randomized controlled trial

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YIN Dawei, SHI Hanyu, WEI Luqing. Meta-analysis of safety and tolerability of prostacyclin analogues for pulmonary arterial hypertension[J]. Medical Journal of the Chinese People Armed Police Forces. 2020, 31(7): 553-556

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