Detection of common respiratory virus antigens in hospitalized children

LUO Li; LONG Bowen; CHEN Xiaojin; LIU Hong

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Medical Journal of the Chinese People Armed Police Forces ›› 2020, Vol. 31 ›› Issue (7) : 565-567.

ORIGINAL ARTICLES

Detection of common respiratory virus antigens in hospitalized children

LUO Li¹, LONG Bowen², CHEN Xiaojin², LIU Hong¹

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Abstract

Objective To find out about the epidemiological characteristics of respiratory viruses in hospitalized children with acute respiratory infections in Pingxiang Maternal and Child Health Hospital.Methods The clinical data of 7656 children with acute respiratory tract infection hospitalized between July 2018 and June 2019 in Pingxiang Maternal and Child Health Hospital was analyzed retrospectively. The antigens of seven common respiratory viruses in nasopharyngeal secretions of children were detected by direct immunofluorescence assay. These seven common respiratory pathogens included respiratory syncytial virus, influenza virus A, influenza virus B, parainfluenza virus Ⅰ, Ⅱ, Ⅲ and adenovirus. Statistical analysis of data was conducted using SPSS19.0 software.Results In the 7,656 cases, the positive rate of at least one virus was 25.57%. The top three viruses were respiratory syncytial virus (13.39%), adenovirus (4.79%) and influenza A virus (3.24%). The rate of virus detection was 30.11% in the group under1 year old, 25.79% in the group aged 1 to less than 3, 21.80% in the group aged 3 to less than 6 and 16.08% in the group aged 6 or above.The younger the age, the higher the detection rate of virus. There was difference of statistical significance in the positive rate of virus between these age groups. The highest detection rate of respiratory syncytial virus was 21.51% in children less than 1 year old and 10.27% in children less than 6 years old. There was no significant difference in the positive rate of the seven viruses between different genders. The incidence of RSV and IFVA infections was the highest in winter and spring, compared with April and June for ADV andIFVB.Other viruses were distributed throughout the year. Twelve of these cases (0.16%) were co-infected with two kinds of viruses.Conclusions Virus is the main pathogen of acute respiratory tract infections in children. The identification of the epidemiology of respiratory tract infection viruses in this area can guide clinical diagnosis and treatment.

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respiratory tract infection / respiratory virus / viral antigen detection

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LUO Li, LONG Bowen, CHEN Xiaojin, LIU Hong. Detection of common respiratory virus antigens in hospitalized children[J]. Medical Journal of the Chinese People Armed Police Forces. 2020, 31(7): 565-567

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