Expression and significance of ALDH1 and CD133 in colorectal carcinoma

DONG Xing; WANG Jing; NIE Yuhui

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Medical Journal of the Chinese People Armed Police Forces ›› 2020, Vol. 31 ›› Issue (7) : 601-604.

ORIGINAL ARTICLES

Expression and significance of ALDH1 and CD133 in colorectal carcinoma

DONG Xing¹, WANG Jing², NIE Yuhui¹

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Abstract

Objective To study the expressions of ALDH1 and CD133 in colorectal carcinoma and their correlations with the occurrence, development and prognosis of colorectal carcinoma.Methods The expressions of ALDH1 and CD133 in 60 cases of colorectal carcinoma, 25 cases of colorectal adenomas and 20 cases of normal colorectal tissues were detected using immunohistochemical methods, and their association with clinicopathological parameters and prognosis was analyzed.Results The positive rate of ALDH1 and CD133 in colorectal carcinoma (78.3%,75.0%) was significantly higher than that in colorectal adenomas (54.5%,48.0%) and normal colorectal tissues (15%,10%) (P<0.05). The expression of ALDH1 was positively correlated with the depth of invasion, TNM stage and lymph node metastasis (P>0.05), but negatively with the degree of differentiation (P>0.05) in colorectal carcinoma. The expression of CD133 in colorectal carcinoma was positively correlated with the depth of invasion, lymph node metastasis and TNM staging (P<0.05). There was a positive correlation between the expressions of ALDH1 and CD133 in colorectal carcinoma (P<0.05). The 5-year survival rate of ALDH1 and CD133 positive patients was significantly lower than that of negative patients (P<0.05).Conclusions The increased expressions of ALDH1 and CD133 are significantly related to the occurrence and development of colorectal carcinoma and may be used as an indicator of the prognosis of colorectal carcinoma.

Key words

aldehyde dehydrogenase 1 / cluster of differentiation 133 / colorectal carcinoma / prognosis

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DONG Xing, WANG Jing, NIE Yuhui. Expression and significance of ALDH1 and CD133 in colorectal carcinoma[J]. Medical Journal of the Chinese People Armed Police Forces. 2020, 31(7): 601-604

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