Objective To investigate the applicability of intravenous administration of the admixture of etomidate and propofol to painless gastroenteroscopy.Methods Between February and May 2019, 240 patients undergoing painless gastroenteroscopy who met the requirements of anesthesia in our hospital were enrolled. These patients were randomly divided into two groups: propofol group (group P) and admixture of etomidate and propofol group (group E-P), with 120 patients in each. Anesthesia was induced by propofol in group P, but by the admixture of etomidate and propofol in group E-P. However, propofol alone was used in either group during maintenance of anesthesia. Non-invasive blood pressure (NBP), heart rate (HR) and saturation of pulse oximetry (SPO2) were monitored during anesthesia. All data was recorded, including the time of anesthesia induction, the time of gastroenteroscopy and awakening, as well as the number of such adverse reactions as circulatory inhibition, respiratory depression, injection pain and myoclonus in either group.Results There was significant difference in the incidence of circulatory inhibition, respiratory depression and injection pain (P=0.0184, P=0.0042, P<0.0001, respectively) between the two groups, which was significantly lower in group E-P(11.67% vs. 24.17%, 8.33% vs. 22.50%, 5.83% vs. 50.83%, respectively). The difference in the incidence of myoclonus was statistically significant (P<0.05), which was higher in group E-P(15.00% vs. 5.83%, P=0.0346).Conclusions The admixture of etomidate and propofol used for anesthesia induction in painless gastroenteroscopy can decrease the incidence of adverse reactions including injection pain and inhibition of circulation and respiration so that it can make painless gastroenteroscopy safer and more comfortable.
Key words
admixture of etomidate and propofol /
propofol /
painless gastroenteroscopy
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