Applicability of serum total bile acid and NT-proBNP levels in prognostic evaluation of patients with chronic heart failure and type 2 diabetes

YU Hong; ZHANG Jiao; ZHANG Lu; JING Limin

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Medical Journal of the Chinese People Armed Police Forces ›› 2021, Vol. 32 ›› Issue (11) : 977-980.

Applicability of serum total bile acid and NT-proBNP levels in prognostic evaluation of patients with chronic heart failure and type 2 diabetes

YU Hong, ZHANG Jiao, ZHANG Lu, JING Limin

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Abstract

Objective To study the applicability of serum total bile acid (TBA) and N terminal pro B type natriuretic peptide (NT-proBNP) in the assessment of prognosis of patients with chronic heart failure (CHF) complicated with type 2 diabetes (T2DM). Methods A total of 146 CHF patients hospitalized in Beijing Electric Power Hospital between October 2019 and June 2020 were selected and divided into the observation group (n=87) and control group (n=59) according to complications with T2DM. The levels of TBA and NT-proBNP in each group were detected, and the clinical value of TBA, NT-proBNP, and their combined detection in the prognosis assessment of CHF patients with T2DM was analyzed respectively by the ROC curve. Results Compared with the control group, the levels of TBA and NT-proBNP in the observation group were significantly increased (P<0.01). Spearmen grade correlation analysis showed that the cardiac function grade in the observation group was positively correlated with TBA levels (r_s=0.633, P<0.01). Pearson correlation analysis showed that the level of TBA in the observation group was positively correlated with the level of NT-proBNP (r=0.539, P<0.01). ROC curve analysis showed that the area under the ROC curve with serum TBA+NT-proBNP combined detection was significantly larger than that of TBA and NT-proBNP used alone(0.942 vs. 0.728 and 0.912, P<0.05). Conclusions Serum TBA levels are significantly increased in CHF patients with T2DM and are positively correlated with cardiac function classification. Serum TBA and NT-proBNP levels can help predict the prognosis of CHF patients with T2DM, and combined detection is better.

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total bile acid / NT-proBNP / heart failure / diabetes / ROC curve

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YU Hong, ZHANG Jiao, ZHANG Lu, JING Limin. Applicability of serum total bile acid and NT-proBNP levels in prognostic evaluation of patients with chronic heart failure and type 2 diabetes[J]. Medical Journal of the Chinese People Armed Police Forces. 2021, 32(11): 977-980

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