Applicability of 18F-FDG PET/CT in patients with suspected local infection after open fractures of lower extremity

YIN Liang; YUE Jianlan; HUANG Shiming; ZHANG Qing; LIU Fei; WANG Qiuju; Lin Zhichun

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Medical Journal of the Chinese People Armed Police Forces ›› 2021, Vol. 32 ›› Issue (2) : 128-131.

ORIGINAL ARTICLES

Applicability of ¹⁸F-FDG PET/CT in patients with suspected local infection after open fractures of lower extremity

YIN Liang, YUE Jianlan, HUANG Shiming, ZHANG Qing, LIU Fei, WANG Qiuju, Lin Zhichun

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Abstract

Objective To evaluate the applicability of ¹⁸F-FDG PET/CT in the positional diagnosis of postoperative infections of open fractures in lower extremities, and its role in debridement surgery.Methods Fifteen patients with suspected chronic local infections following surgeries for traumatic fractures of lower extremities were recruited between July 2018 and June 2019. PET/CT examination was performed one week before debridement. Infection lesions were positioned according to PET/CT images and compared with results of postoperative pathology, microbial culture and PET/CT. The mean SUVmax of bone infections and soft tissue infections was calculated, while the findings of PET/CT and SPECT/CT imaging of one patient were analyzed. The effect of PET/CT-guided debridement was assessed.Results Among the 15 patients, 6 had simple bone infection lesions, 3 had simple soft tissue infection lesions, and the other 6 patients had both bone infection lesions and soft tissue infection lesions. A total of 18 bone infection lesions and 12 soft tissue infection lesions were found by PET/CT. The SUVmax of bone infection lesions was 5.1±3.4, compared with 3.6±2.4 for soft tissue infection lesions. The diagnostic sensitivity of PET/CT for bone infections and soft tissue infections was 94.4% and 83.3% respectively. The sensitivity of PET/CT was higher than that of SPECT/CT imaging. Under the guidance of PET/CT, the cure rate of patients with open fractures in lower extremities after one debridement was 93.3% (14/15).Conclusions The accuracy of ¹⁸F-FDG PET/CT in the diagnosis of postoperative infections of open fractures of lower extremities is high, and the effect of guided debridement is reliable.

Key words

open fracture / infection / PET/CT / deoxyglucose / debridement

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YIN Liang, YUE Jianlan, HUANG Shiming, ZHANG Qing, LIU Fei, WANG Qiuju, Lin Zhichun. Applicability of ¹⁸F-FDG PET/CT in patients with suspected local infection after open fractures of lower extremity[J]. Medical Journal of the Chinese People Armed Police Forces. 2021, 32(2): 128-131

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