Effects of N-acetylcysteine on levels of inflammatory factors and pulmonary surfactant protein in alveolar lavage fluid of acute lung injury

LIU Tai; LI Ya; DU Weiqi; WANG Lijun; WANG Hongfei

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Medical Journal of the Chinese People Armed Police Forces ›› 2021, Vol. 32 ›› Issue (6) : 464-467.

Effects of N-acetylcysteine on levels of inflammatory factors and pulmonary surfactant protein in alveolar lavage fluid of acute lung injury

LIU Tai, LI Ya, DU Weiqi, WANG Lijun, WANG Hongfei

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Abstract

Objective To investigate the effect of N-acetylcysteine on levels of inflammatory factors and pulmonary surfactant protein in bronchoalveolar lavage fluid (BALF) after acute lung injury. Methods One hundred patients with acute lung injury admitted to our hospital between February 2017 and January 2020 were selected and randomly divided into the control group (50 cases) and observation group (50 cases). After admission, both groups were given bronchoalveolar lavage and mechanical ventilation. The control group was given conventional treatment, and the observation group was additionally treated with N-acetylcysteine. The lung function indexes and oxygen saturation of the two groups after treatment were observed. The expressions of TNF-α, IL-1 β and NF kb in BALF were compared between the two groups before and after treatment. The changes of surfactant protein-A (SP-A) and surfactant protein-B (SP-B) were observed before and after treatment. Results After treatment, the blood gas indexes and pulmonary function indexes of the observation group were better than those of the control group (P<0.05), and the levels of TNF - α, IL-1 β and NF kb in BALF of the two groups were decreased, especially in the observation group (P<0.05). After treatment, the levels of SP-A and SP-B in the observation group were significantly higher than those of the control group (P<0.05). Conclusions Acetylcysteine solution for inhalation can reduce the inflammatory response of acute lung injury, improve the patients' lung function, increase the level of lung surfactant protein, and help protect against lung injury. It is clinically worthy of application.

Key words

acetylcysteine solution for inhalation / acute lung injury / inflammatory factor / surfactant protein / lung protection

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LIU Tai, LI Ya, DU Weiqi, WANG Lijun, WANG Hongfei. Effects of N-acetylcysteine on levels of inflammatory factors and pulmonary surfactant protein in alveolar lavage fluid of acute lung injury[J]. Medical Journal of the Chinese People Armed Police Forces. 2021, 32(6): 464-467

References

[1] Pavlisko E N, Neely M L, Kopetskie H, et al. Occurrence and risk factors for acute lung injury and organizing pneumonia after lung transplant[J]. J Heart Lung, 2019, 38(4):S56-S57.
[2] Wen J, Zhong D, Hui H, et al.Inhibition of glycolysis alleviates lipopolysaccharide-induced acute lung injury in a mouse model[J]. J Cell Physiol, 2019,234(4):4641-4654.
[3] Zou Y, Bao S, Wang F, et al. FN14 blockade on pulmonary microvascular endothelial cells improves the outcome of sepsis-induced acute lung injury[J]. Shock, 2018,49(2):213-220.
[4] 刘学芳, 冯素香, 田燕歌, 等. 肺泡表面活性物质与慢性阻塞性肺疾病研究进展[J]. 中国老年学杂志, 2018, 38(6):1521-1523.
[5] 陶欢, 徐尤年, 付丽莎, 等. 厄洛替尼在小鼠急性肺损伤中作用及对肺表面活性物质相关蛋白A表达的影响[J]. 中华急诊医学杂志, 2018, 27(8):881-886.
[6] 吴哲乾, 戴李华. 血液净化联合乌司他丁治疗脓毒症急性肺损伤的疗效和对基质金属蛋白酶水平的影响[J]. 安徽医药, 2019, 23(12):2382-2385.
[7] 郝文东, 王国芳, 张彩莲, 等. 吸入用乙酰半胱氨酸溶液联合双水平气道正压通气治疗AE-COPD合并Ⅱ型呼吸衰竭的疗效及作用机制研究[J]. 现代中西医结合杂志, 2018, 27(7):724-727.
[8] 中华医学会重症医学分会. 急性肺损伤/急性呼吸窘迫综合征诊断与治疗指南(2006)[J]. 中华内科杂志, 2007, 16(5):21-22.
[9] 董兰, 王乃田, 陈晓阳,等. 不同剂量乌司他丁联合肺保护性通气对肝移植手术患者的肺保护作用[J]. 武警医学, 2019, 30(6):513-517.
[10] Tao H, Li N, Zhang Z, et al. Erlotinib protects LPS-induced acute lung injury in mice by inhibiting egfr/tlr4 signaling pathway[J]. Shock, 2019,51(1):131-138.
[11] 张亚楠, 殷桂林. 单肺通气的肺损伤机制及肺保护策略研究进展[J]. 华南国防医学杂志, 2018, 32(4):69-72.
[12] 王晶, 李亚, 李建生,等. 调补肺肾系列方药对PM 2.5致肺损伤大鼠炎性反应因子和氧化应激的影响[J]. 中医杂志, 2019, 60(5):415-421.
[13] Yang Z, Zhang X, Zhao Q, et al. Knockdown of TNFα alleviates acute lung injury in rats with intestinal ischemia and reperfusion injury by upregulating IL-10 expression[J]. Int J Mol Med, 2018,42(2):926-934.
[14] Mizushina Y, Karasawa T, Aizawa K, et al. Inflammasome-independent and atypical processing of il-1β contributes to acid aspiration-induced acute lung injury[J]. J Immun, 2019, 203(1):236-246.
[15] Wang B Q, Shi M, Zhang J P, et al. Knockdown of tfpi-anchored endothelial cells exacerbates lipopolysaccharide-induced acute lung injury via NF-κB signaling pathway[J]. Shock, 2019,51(2):235-246.
[16] Arroyo R, Martin G A, Echaide M, et al. Supramolecular assembly of human pulmonary surfactant protein SP-D[J]. J Mol Biol, 2018,430(10):1495-1509.
[21] Jules L. Commentary: surfactant protein a and d polymorphisms: personalized medicine or a day at the SP-A[J]. J Thorac Cardiovasc Surg, 2019,157(5):2119-2120.
[17] Lin M C, Shen C H, Chang D, et al. Inhibition of human lung adenocarcinoma growth and metastasis by JC polyomavirus-like particles packaged with an SP-B promoter-driven CD59-specific shRNA[J]. Clin Ence, 2019, 133(21):2159-2169.