Effects of spermidine on bone microstructure of femurs of senile mice

SU Jingke; SU Jinghua; HAN Ning; TIAN Xiaoyu; DANG Ruijie; FENG Jin; GENG Yanqiu

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Medical Journal of the Chinese People Armed Police Forces ›› 2022, Vol. 33 ›› Issue (1) : 42-45.

Effects of spermidine on bone microstructure of femurs of senile mice

SU Jingke¹, SU Jinghua², HAN Ning¹, TIAN Xiaoyu³, DANG Ruijie³, FENG Jin³, GENG Yanqiu¹

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Abstract

Objective To investigate the effects of spermidine on bone microstructure of femurs of senile mice. Methods Twenty 21-month-old C57 mice were randomly divided into the vehicle group (n=10 ) and spermidine group (3 mmol/L spermidine in drinking water, n=10). Body weight was measured weekly during the study. After 12 weeks of intervention, biochemical indexes of bone metabolism in serum and urine were tested and histomorphometry of femurs was measured by micro-CT (microcomputed tomography). Results Compared with the vehicle mice, spermidine had no effect on the weight of senile mice. Spermidine intervention significantly increased serum levels of ALP (P＜0.05), elevated the trabecular bone volume per tissue volume (Tb.BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th)and bone mineral density (BMD), and reduced trabecular separation (Tb.Sp). Conclusions Spermidine attenuates age-associated osteoporosis in senile mice.

Key words

spermidine / alkaline phosphatase / senile mice / osteoporosis

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SU Jingke, SU Jinghua, HAN Ning, TIAN Xiaoyu, DANG Ruijie, FENG Jin, GENG Yanqiu. Effects of spermidine on bone microstructure of femurs of senile mice[J]. Medical Journal of the Chinese People Armed Police Forces. 2022, 33(1): 42-45

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