Value of FICE combined with gastrin-17 in diagnosis of early gastric cancer and precancerous lesions

WANG Yuexing; DENG Lijuan; HU Jing; WANG Ruilan

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Medical Journal of the Chinese People Armed Police Forces ›› 2022, Vol. 33 ›› Issue (11) : 957-959.

Value of FICE combined with gastrin-17 in diagnosis of early gastric cancer and precancerous lesions

WANG Yuexing¹, DENG Lijuan¹, HU Jing², WANG Ruilan¹

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Abstract

Objective To analyze the diagnostic value of Fuji intelligent chromo-endoscopy (FICE) combined with gastrin-17 (G-17) for early gastric cancer and precancerous lesions. Methods Two hundred and sixty patients admitted to the hospital from January 2017 to January 2020 were selected for digestive endoscopy. FICE was used to magnify endoscopy, and the fasting serum G-17 was analyzed by enzyme linkedbent assay (ELISA). Statistical analysis of the efficacy of FICE magnifying endoscopy combined with G-17 in the diagnosis of early gastric cancer and precancerous lesions. Results Compared with conventional magnifying endoscopy, FICE could improve the image clarity of the morphology and structure of the gastric mucosa and the opening of the glandular canal (P<0.05). Sensitivity, specificity and accuracy of FICE combined with G-17 in diagnosis of early gastric cancer were 91.94%, 98.48%, and 96.92%, higher than FICE (64.52%, 98.99%, and 90.77%). Conclusions FICE magnifying endoscopy combined with G-17 has a higher screening and detection rate for early gastric cancer and precancerous lesions, which is of high clinical value.

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electronic spectroscopic endoscopy / magnifying endoscope / gastrin-17 / gastric cancer / precancerous lesions

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WANG Yuexing, DENG Lijuan, HU Jing, WANG Ruilan. Value of FICE combined with gastrin-17 in diagnosis of early gastric cancer and precancerous lesions[J]. Medical Journal of the Chinese People Armed Police Forces. 2022, 33(11): 957-959

References

[1] 乔京贵, 赵聪亚, 张淑芬, 等. 黏膜剥离术联合色素内镜行胃黏膜病变活检在提高早期胃癌和癌前病变检出率中的应用[J]. 陕西医学杂志, 2017, 46(12): 1733-1734.
[2] 王蓉, 邓传婕, 朱军, 等. 内镜下醋酸染色联合窄带光成像对早期胃癌及癌前病变的诊断价值[J].中华消化内镜杂志, 2019, 36(2):91-97.
[3] 陆欢华, 刘铁梅. 色素内镜对早期胃癌和癌前病变诊断效果的临床研究[J].哈尔滨医科大学学报, 2018, 52(6):577-580.
[4] 杨珍明, 沈磊. 蓝激光成像结合放大内镜对早期胃癌及癌前病变的诊断价值[J].中华消化内镜杂志, 2017, 34(1):24-29.
[5] Yu G, Wang G X, Wang H G, et al. The value of detecting pepsinogen and gastrin-17 levels in serum for pre-cancerous lesion screening in gastric cancer[J]. Neoplasma, 2019, 66(4):637-640.
[6] 孙锦晨, 崔俊, 黄留业. 蓝激光成像技术与智能分光比色技术对早期胃癌诊断价值的研究[J].中国内镜杂志, 2018,24(10):49-52.
[7] 陈光勇, 黄受方. WHO消化系统肿瘤分类第5版关于胃癌的解读:着重对早期胃癌的理解和认识[J].中华病理学杂志, 2020, 49(9):4.
[8] 薛辉, 辛凤池, 穆素恩, 等.血清胃蛋白酶原联合G-17对萎缩性胃炎及胃癌早期诊断价值[J].现代生物医学进展, 2017, 17(11): 2119-2122.
[9] 郭浩, 关晓辉. 胃泌素17与CA7-24联合检测在胃癌诊断中的价值[J].北华大学学报(自然科学版), 2019, 20(6): 775-777.
[10] 黄喜顺, 苏军凯, 邓立新, 等. PG、G-17、CA72-4、CEA联合检测在胃癌筛查中的应用[J].西北国防医学杂志, 2019, 40(6):341-346.
[11] Tajiri H, Matsuda K, Fujisaki J. What can we see with the endoscope? Present status and future perspectives[J]. Digestive Endoscopy, 2010, 14(4):131-137.
[12] Cassinotti A, Buffoli F, Fociani P, et al.Virtual chromoendoscopy with fice for the classification of polypoid and nonpolypoid raised lesions in ulcerative colitis[J]. J Clin Gastroenterol,2019,53(4):269-276.
[13] 刘鑫, 张静, 王晔, 等.早期胃癌白光内镜下特征分析[J].北京大学学报:医学版, 2019, 51(2): 112- 116.
[14] Kenshi, Yao, Hisashi, et al. Diagnostic performance and limitations of magnifying narrow-band imaging in screening endoscopy of early gastric cancer: a prospective multicenter feasibility study[J]. Gastric Cancer, 2014, 17(4):669-679.
[15] Okada K, Fujisaki J, Kasuga A, et al. Diagnosis of undifferentiated type early gastric cancers by magnification endoscopy with narrow-band imaging[J]. J Gastroen Hepatol, 2011, 26(8):1262-1269.
[16] Zhao W X, Liu Z F, Li X L, et al. Correlations of serum homocysteine,VEGF and gastrin 17 with gastric cancer and precancerous lesions[J]. Eur Rev Med Pharmacol Sci,2019,23(10):4192-4198.
[17] 李梦颖, 马晨, 焦晨阳, 等. 血清胃蛋白酶原和胃泌素-17在胃癌和癌前病变筛查中的价值[J].胃肠病学, 2017, 22(9): 539-543.
[18] 陈艳红, 胡俊, 李志晋, 等. 胃蛋白酶原联合FICE放大内镜对胃癌及癌前病变的诊断价值[J].实用癌症杂志, 2019, 34(10): 1677-1679.