Objective To explore the risk factors of congenital cataracts in Chinese population.Methods CNKI, VIP, WanFang Data, Pubmed and Embase databases were searched from inception to November 30th, 2021. Meta-analysis was conducted with RevMan5.4 software.Results Six articles were included, with a total of 650 cases and 1353 controls. The meta-analysis results showed that the risk factors for congenital cataract in the Chinese population were as follows, oxygen therapy after birth (OR=5.50, 95%CI: 1.66-18.20), family genetic history (OR=6.97, 95%CI: 2.76-17.62), infections during pregnancy (OR=2.06, 95%CI: 1.38-3.06), poor nutritional status during pregnancy (OR=2.55, 95%CI: 1.17-5.56), medications during pregnancy (OR=4.49, 95%CI: 1.74-11.59), suffering from ischemic hypoxic encephalopathy (OR=6.42, 95%CI: 1.35-30.53), premature delivery (OR=2.14, 95%CI: 1.28-3.60), low birth weight (OR=4.04, 95%CI: 2.11-7.75), peripheral blood serum complement C3 level decreased (OR=1.04, 95%CI: 1.02-1.07), CRYAA and CRYAB gene single nucleotide polymorphism: CRYAArs7278468 GT+TT allele (OR=6.03, 95%CI: 1.27-28.53), CRYABrs370803064 AA+GA allele (OR=5.81, 95%CI: 1.57-21.56), CRYABrs387907338 TT+TC allele (OR=2.47, 95%CI: 1.34-4.58), and CRYAB gene TA haplotype (OR=1.80, 95%CI: 1.10-2.95).Conclusions Congenital cataract is influenced by many factors, among which drug use during pregnancy, low birth weight, hypoxic ischemic encephalopathy and postnatal oxygen therapy are the most influential factors.
Key words
Chinese /
congenital cataract /
incidence /
risk factors /
Meta-analysis
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References
[1] 李卫红,张新媛,云 波,等.先天性白内障病因的多因素分析[J].眼科,2004,13(5):288-290.
[2] Tekin K, Erol Y O, Inanc M, et al. Electron microscopic evaluation of anterior lens epithelium in patients with idiopathic congenital cataract[J]. Int Ophthalmol, 2018, 38(5): 2127-2132.
[3] Chan W H, Biswas S, Ashworth J L, et al. Congenital and infantile cataract: aetiology and management[J]. Eur J Pediatr, 2012, 171(4): 625-630.
[4] Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses[J]. Eur J Epidemiol, 2010, 25(9): 603-605.
[5] 宋毅果. 非家族遗传性先天性白内障危险因素研究[D].西安:第四军医大学,2010.
[6] Cui X J, Lv F Y, Li F H, et al. Correlations of single nucleotide polymorphisms of CRYAA and CRYAB genes with the risk and clinicopathological features of children suffering from congenital cataract[J]. Medicine (Baltimore), 2017, 96(25): e7158.
[7] 罗 琪,周炼红,田明星,等.146例先天性白内障发生的相关因素分析[J].临床眼科杂志,2014,22(3):230-233.
[8] 霍 璐.93例先天性白内障高危影响因素分析[J].齐齐哈尔医学院学报,2021,42(5):395-398.
[9] 邵明希,李圣杰,滕济森,等.血清补体C3水平与先天性白内障的相关性研究[J].中国眼耳鼻喉科杂志,2019,19(3):176-179.
[10] Taylan S H, Utine G E. Congenital cataract and its genetics: the era of next-generation sequencing[J]. Turk J Ophthalmol, 2021, 51(2): 107-113.
[11] Gonzalez-Huerta L M, Messina-Baas O, Urueta H, et al. A CRYGC gene mutation associated with autosomal dominant pulverulent cataract[J]. Gene, 2013, 529(1): 181-185.
[12] Xia X Y, Wu Q Y, An L M, et al. A novel P20R mutation in the alpha-B crystallin gene causes autosomal dominant congenital posterior polar cataracts in a Chinese family[J]. BMC Ophthalmol, 2014, 14(1): 108.
[13] Palmquist B M, Philipson B, Barr P O. Nuclear cataract and myopia during hyperbaric oxygen therapy[J]. Br J Ophthalmol, 1984, 68(2): 113-117.
[14] Nguyen T V, Pham V H, Abe K. Pathogenesis of congenital rubella virus infection in human fetuses: viral infection in the ciliary body could play an important role in cataractogenesis[J].EBio Medicine, 2015, 2(1): 59-63.
[15] Delcourt C, Dupuy A M, Carriere I, et al. Albumin and transthyretin as risk factors for cataract: the pola study[J]. Arch Ophthalmol, 2005, 123(2): 225-232.
[16] 陈 勇,薄 涛,里 健,等.围生期窒息继发白内障11例临床分析[J].实用临床医学,2006,7(10):133-135,137.
[17] Eckstein M, Vijayalakshmi P, Killedar M, et al. Aetiology of childhood cataract in south India[J]. Br J Ophthalmol, 1996, 80(7): 628-632.
[18] Bhatti T R, Dott M, Yoon P W, et al. Descriptive epidemiology of infantile cataracts in metropolitan Atlanta, GA, 1968-1998[J]. Arch Pediatr Adolesc Med, 2003, 157(4): 341-347.
[19] Prakalapakorn S G, Rasmussen S A, Lambert S R, et al. Assessment of risk factors for infantile cataracts using a case-control study: national birth defects prevention study, 2000-2004[J]. Ophthalmology, 2010, 117(8): 1500-1505.
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