Objective To assess the clinical effect of CGF in preservation of the alveolar ridge and amelioration of postoperative responses after tooth extraction.Methods Such electronic databases as Pubmed, Embase, Cochrane Library , Wanfang, CJFD, VIP, CQVIP and CBM were searched. The quality of the included studies was assessed using the Cochrane manual, and a meta-analysis was performed by using Revman 5.4.1.Results A total of 13 RCTs were included, 4 in English and 9 in Chinese. CGF could effectively reduce not only the height and width changes of the alveolar ridge after tooth extraction[MD=-1.67(-2.05,-1.29), P<0.05], but also the incidence of dry sockets after tooth extraction[OR=0.11 (0.03,0.38), P<0.05], but it could not effectively improve mouth opening after mandibular third molar extraction[MD=-0.27(-6.23, 1.89), P>0.05]. Based on qualitative analysis, the effect of CGF on improving the swelling of mandibular third molar after extraction was not clear, but it could alleviate the postoperative pain.Conclusions CGF has a good clinical effect in preserving the alveolar ridge and ameliorating postoperative responses after tooth extraction.
Key words
concentrated growth factor /
alveolar ridge preservation /
reaction after tooth extraction /
meta-analysis
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] Tan W L, Wong T L, Wong M C, et al. A systematic review of post-extractional alveolar bone dimensional changes in humans[J]. Clin Oral Implants Res, 2012, 23(suppl 5):1-21.
[2] Wang L, Wan M, Li Z, et al. A comparative study of the effects of concentrated growth factors in two different forms on osteogenesis in vitro[J].Mol Med Rep, 2019, 20(2):1039-1048.
[3] Effect of low-concentration povidone iodine on postoperative complications after third molar surgery: a pilot split-mouth study[J]. J Oral Maxillofac Surg, 2015, 73(1):18-21.
[4] Kumar N, Prasad K, Ramanujam L, et al. Evaluation of treatment outcome after impacted mandibular third molar surgery with the use of autologous platelet-rich fibrin: a randomized controlled clinical study[J]. J Oral Maxillofac Surg, 2015, 73(6):1042-1049.
[5] Hauser F, Gaydarov N, Badoud I, et al. Clinical and histological evaluation of postextraction platelet-rich fibrin socket filling: a prospective randomized controlled study[J]. Implant Dent,2013, 22(3):295-303.
[6] Qin J, Wang L, Sun Y, et al. Concentrated growth factor increases Schwann cell proliferation and neurotrophic factor secretion and promotes functional nerve recovery in vivo[J]. Int J Mol Med, 2016, 37(2):493-500.
[7] Ma F, Lin Y, Sun F, et al. The impact of autologous concentrated growth factors on the alveolar ridge preservation after posterior tooth extraction: a prospective, randomized controlled clinical trial[J].Clin Implant Dent Relat Res, 2021,18:453.
[8] Torul D, Omezli M M, Kahveci K. Evaluation of the effects of concentrated growth factors or advanced platelet rich-fibrin on postoperative pain, edema, and trismus following lower third molar removal: A randomized controlled clinical trial-ScienceDirect[J].J Oral Maxillofac Surg, 2020, 37(2): 500.
[9] 陈文飞, 黎艳会.浓缩生长因子联合骨替代用品在上颌前牙区拔牙位点保存中的临床应用[J]. 中外医学研究, 2018, 16(22): 107-108.
[10] 梁向新. CGF复合骨诱导活性材料在拔牙位点保存中的应用效果评价[J]. 实用中西医结合临床, 2018, 18(12):59-61.
[11] 蔺世晨, 段少宇, 朱 静, 等. 浓缩生长因子联合骨代用品在上颌前牙区拔牙位点保存中的临床应用[J]. 首都医科大学学报, 2017, 38(3): 451-456.
[12] 徐海龙, 张 辉, 赵 蜜, 等. 浓缩生长因子复合人工骨材料的磨牙位点保存效果评价[J]. 中国实用口腔科杂志, 2020, 13(12):47-51.
[13] 朱 梅, 孙 强, 邓佳蕴, 等. CGF联合骨代用品在美学区拔牙位点保存中的临床应用[J]. 中国美容医学, 2019, 28(11):100-103.
[14] Koyuncu B Z, Ik G, Yuce M Z, et al Effect of concentrated growth factor (cgf) on short term clinical outcomes after partially impacted mandibular third molar surgery: a split-mouth randomized clinical study[J]. J Oral Maxillofac Surg, 2019, 121(2):45.
[15] 龚仁国, 阙佳佳, 肖海鹰,等. CGF对下颌阻生第三磨牙拔除术后生活质量的影响[J]. 全科口腔医学电子杂志, 2016,12(2):1-2.
[16] 龚仁国, 阙佳佳, 罗纯锐,等. CGF在预防下颌阻生第三磨牙拔除术后并发症中的应用[J]. 成都医学院学报, 2016,12(1):82-84.
[17] 任道普, 曹 洋, 任蓓萱. 浓缩生长因子在下颌阻生第三磨牙拔牙创愈合中的作用观察[J]. 实用医院临床杂志, 2019, 16(3):40-42.
[18] Koyuncu B Z, Ik G, Yuce M Z, et al. Effect of concentrated growth factors on frequency of alveolar Osteitis following partially-erupted mandibular third molar surgery: a randomized controlled clinical study[J]. BMC oral health, 2020, 20(1):222.
[19] 姚淑萍, 钱雅萍, 邹 韵. 自体CGF凝胶植入拔牙创预防干槽症发生的研究[J]. 浙江创伤外科, 2020, 25(2):331-332.
[20] Susin C, Fiorini T, Lee J, et al. Wound healing following surgical and regenerative periodontal therapy[J]. Periodontol ,2000, 68(1):83-98.
[21] 王立军,王 晴,候文辉,等. 改良型富血小板纤维蛋白预防下颌阻生智齿拔除术后并发症的效果[J]. 武警医学,2021,32(4):300-303.
[22] Yüce, Kmerik. Potential effects of advanced platelet rich fibrin as a wound-healing accelerator in the management of alveolar osteitis: A randomized clinical trial[J]. Niger J Clin Pract, 2019, 22(9):1189-1195.
[23] Fang D, Long Z, Hou J. Clinical application of concentrated growth factor fibrin combined with bone repair materials in jaw defects[J].J Oral Maxillofac Surg,2020, 78(6):882-892.
PDF(1005 KB)
