Clinical study of quetiapine combined with memantine in treatment of BPSD of Alzheimer's disease and its influence on the mental burden of caregivers

LIU Peng; LI Zhiyong; DUAN Feng; WANG Qian

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Medical Journal of the Chinese People Armed Police Forces ›› 2022, Vol. 33 ›› Issue (5) : 423-426.

Clinical study of quetiapine combined with memantine in treatment of BPSD of Alzheimer's disease and its influence on the mental burden of caregivers

LIU Peng¹, LI Zhiyong², DUAN Feng³, WANG Qian⁴

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Abstract

Objective To investigate the clinical effect of quetiapine combined with memantine in the treatment of behavioral and psychological symptoms of dementia (BPSD)of Alzheimer's disease and its influence on the mental burden of the caregivers. Methods Sixty male patients diagnosed as AD combined with BPSD who were treated in The Sixth Medical Center of Chinese PLA General Hospital from January 2020 to January 2021 as well as 60 caregivers were randomly divided into experimental group (n=30) and control group (n=30). The control group were treated with Memantine, while the experimental group were treated with memantine combined with quetiapine for 4 weeks. Before treatment and at the end of 4 weeks' treatment, evaluation of MoCA, BEHAVE-AD and their caregivers' SCL-90 scores was made. Results Before treatment of both groups, there was no significant difference (P>0.05) in MoCA, BEHAVE - AD and caregivers' SCL-90 score. MoCA scores in both groups after treatment were improved, and the difference was statistically significant (P<0.05). After treatment, the BEHAVE-AD score and caregiver SCL-90 score in the experimental group were improved, and the difference was statistically significant (P<0.05), while those scores in the control group were not improved and there was no statistical difference (P>0.05). Conclusions Quetiapine combined with memantine has a better therapeutic effect and it can also help relieve the mental burden of the patient's caregivers.

Key words

Alzheimer's disease / dementia / behavioral and psychological symptoms / quetiapine / caregiver burden

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LIU Peng, LI Zhiyong, DUAN Feng, WANG Qian. Clinical study of quetiapine combined with memantine in treatment of BPSD of Alzheimer's disease and its influence on the mental burden of caregivers[J]. Medical Journal of the Chinese People Armed Police Forces. 2022, 33(5): 423-426

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